Hereditary recurrent fevers (HRFs) are a group of monogenic autoinflammatory diseases
characterised by recurrent bouts of fever and serosal inflammation that are caused by …

… ū B cells, B-cell activating factor receptor (BAFF-R) on B cells, and the inducible co-stimulator
(ICOS) on … CD19 on B cells BAFF-R on B cells ICOS on activated T cells X-linked HIGM …

Stimulator of interferon genes (STING) is essential for the type I interferon response against
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …

Early-onset sarcoidosis (EOS) and inheritable Blau syndrome (BS) share characteristic
clinical features of juvenile-onset systemic granulomatosis syndrome that mainly affects skin, …

To further understand the interaction among GATA-3, Stat4, and T-bet in helper T cell
development, we first showed that retroviral expression of GATA-3 in developing Th1 cells …

… Ryuta Nishikomori, Department of Pediatrics, Kyoto University Graduate School of Medicine…
Ohara and Nishikomori had full access to all of the data in the study and take responsibility …

Establishment of an assay capable of generating all classes of human lymphocytes from
hematopoietic stem cells (HSCs) will provide new insight into the mechanism of human …

Background Severe combined immunodeficiency (SCID) is a syndrome characterized by
profound T-cell deficiency. BCG vaccine is contraindicated in patients with SCID. Because most …

T helper 1 (T H 1) differentiation and IFN-γ production are crucial in cell-mediated immune
responses. IL-12 is an important regulator of this process and mediates its effects through …

Aicardi-Goutières syndrome (AGS) is a rare, genetically determined early-onset progressive
encephalopathy. To date, mutations in six genes have been identified as etiologic for AGS. …