Glucotoxicity and β-cell failure in type 2 diabetes mellitus

Ν Kaiser, G Leibowitz, R Nesher - Journal of Pediatric Endocrinology …, 2003 - degruyter.com
… Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E,
Nesher R. Translocation inhibitors define specificity of protein kinase C isoenzymes in …

Modeling phasic insulin release: immediate and time-dependent effects of glucose

R Nesher, E Cerasi - Diabetes, 2002 - Am Diabetes Assoc
… (For discussion on the role of protein kinase C, see Nesher et al. in this supplement; several
Nesher R, Cerasi E: Biphasic insulin release as the expression of combined inhibitory and …

Risk factors for cranial ischemic complications in giant cell arteritis

G Nesher, Y Berkun, M Mates, M Baras, R Nesher… - Medicine, 2004 - journals.lww.com
Cranial ischemic complications (CICs) are among the presenting manifestations of giant cell
arteritis (GCA). Yet patients with GCA may develop CICs at a later stage, despite steroid …

Dissociation of effects of insulin and contraction on glucose transport in rat epitrochlearis muscle

R Nesher, IE Karl, DM Kipnis - American Journal of …, 1985 - journals.physiology.org
The effects of insulin and contraction on glucose transport and metabolism were investigated
in rat epitrochlearis muscles in vitro. Insulin dose-response curves showed a threshold (…

[HTML][HTML] Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to …

…, J Francis, JC Garmey, JC Schisler, R Nesher… - Journal of Biological …, 2005 - ASBMB
The homeodomain factor Pdx-1 regulates an array of genes in the developing and mature
pancreas, but whether regulation of each specific gene occurs by a direct mechanism (binding …

[HTML][HTML] Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic β-cells

…, D Ron, E Abramovitch, E Cerasi, R Nesher - Journal of Biological …, 1997 - ASBMB
The protein kinase C (PKC) family consists of 11 isoenzymes. Following activation, each
isoenzyme translocates and binds to a specific receptor for activated Ckinase(RACK) (Mochly-…

Rate of discordant findings in bilateral temporal artery biopsy to diagnose giant cell arteritis

GS Breuer, G Nesher, R Nesher - The Journal of Rheumatology, 2009 - jrheum.org
Objective. To determine to what extent performing simultaneous bilateral temporal artery
biopsies might increase the diagnostic sensitivity in giant cell arteritis (GCA). Methods. In total …

[PDF][PDF] Effect of biopsy length on the rate of positive temporal artery biopsies

GS Breuer, R Nesher, G Nesher - Clinical & Experimental …, 2009 - clinexprheumatol.org
Objectives. To investigate the relationship between temporal artery biopsy (TAB) length and
the diagnostic sensitivity for giant cell arteritis (GCA). Methods. TAB pathology reports were …

β-cell protein kinases and the dynamics of the insulin response to glucose

R Nesher, E Anteby, M Yedovizky, N Warwar… - Diabetes, 2002 - Am Diabetes Assoc
… 6 in the article by Cerasi and Nesher in this issue). … ) (see article by Cerasi and Nesher in
this issue) and the slope of … (TDI) (see article by Cerasi and Nesher in this issue) (Fig. 2 and …

Epitrochlearis muscle. I. Mechanical performance, energetics, and fiber composition

R Nesher, IE Karl, KE Kaiser… - American Journal of …, 1980 - journals.physiology.org
An in vitro rat muscle preparation is described that can contract at rates of 12–240 twitches/min.
Maximum dF/dt paralleled maximum twitch tension, their ratio being constant at …