Polymyositis and dermatomyositis

MC Dalakas, R Hohlfeld - The Lancet, 2003 - thelancet.com
The inflammatory myopathies, commonly described as idiopathic, are the largest group of
acquired and potentially treatable myopathies. On the basis of unique clinical, …

Multiple sclerosis: side effects of interferon beta therapy and their management

EU Walther, R Hohlfeld - Neurology, 1999 - AAN Enterprises
Article abstract Interferon beta (IFNβ) reduces the relapse rate, disease activity as measured
by serial MRI scanning, and disease progression of MS. Therapy with IFNβ may be …

Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives.

R Hohlfeld - Brain: a journal of neurology, 1997 - academic.oup.com
… TNF-R could also be engineered by genetically linking two TNF-R domains via a linker
peptide not related to Ig. Such phosphodiesterase type IV (Sinha et al., 1995), has shown …

[HTML][HTML] A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis

…, P O'Connor, C Polman, R Hohlfeld… - … England Journal of …, 2010 - Mass Medical Soc
Background Oral fingolimod, a sphingosine-1-phosphate–receptor modulator that prevents
the egress of lymphocytes from lymph nodes, significantly improved relapse rates and end …

Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of …

…, H Lassmann, H Wekerle, R Hohlfeld - The Journal of …, 1999 - rupress.org
Brain-derived neurotrophic factor (BDNF) has potent effects on neuronal survival and plasticity
during development and after injury. In the nervous system, neurons are considered the …

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase …

…, N Goebels, R Hohlfeld, M Friese, R Schröder… - The Journal of …, 2000 - rupress.org
Clonal composition and T cell receptor (TCR) repertoire of CD4 + and CD8 + T cells
infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with …

Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment

…, T Derfuss, C Hartle, J Newcombe, R Hohlfeld… - Brain, 2006 - academic.oup.com
Understanding the mechanisms of immune cell migration to multiple sclerosis lesions offers
significant therapeutic potential. This study focused on the chemokines CXCL12 (SDF-1) …

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

…, R Bittner, H Lassmann, H Wekerle, R Hohlfeld… - Brain, 2009 - academic.oup.com
We established microRNA profiles from active and inactive multiple sclerosis lesions. Using
laser capture microdissection from multiple sclerosis lesions to pool single cells and in vitro …

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

…, SE Baranzini, T Kümpfel, R Hohlfeld… - Proceedings of the …, 2017 - National Acad Sciences
There is emerging evidence that the commensal microbiota has a role in the pathogenesis
of multiple sclerosis (MS), a putative autoimmune disease of the CNS. Here, we compared …

Neurofascin as a novel target for autoantibody-mediated axonal injury

…, A Moldenhauer, S Velhin, R Hohlfeld… - The Journal of …, 2007 - rupress.org
Axonal injury is considered the major cause of disability in patients with multiple sclerosis (MS),
but the underlying effector mechanisms are poorly understood. Starting with a proteomics…