[HTML][HTML] Chronic inflammation in non-alcoholic steatohepatitis: molecular mechanisms and therapeutic strategies

C Luci, M Bourinet, PS Leclère, R Anty… - Frontiers in …, 2020 - frontiersin.org
… LSECs display anti-inflammatory and anti-fibrogenic properties by preventing Kupffer cell
and hepatic stellate cell activation and regulating hepatic lipid metabolism [reviewed in (36)]. …

[HTML][HTML] Metabolic fatty liver disease in children: A growing public health problem

S Le Garf, V Nègre, R Anty, P Gual - Biomedicines, 2021 - mdpi.com
… In addition, it also plays a hepatic anti-inflammatory and anti-fibrotic role, by reducing
proinflammatory cytokines and the activation and proliferation of hepatic stellate cells. Two main …

Management of diabetes mellitus in patients with cirrhosis: An overview and joint statement

J Boursier, R Anty, C Carette, B Cariou, L Castera… - Diabetes & …, 2021 - Elsevier
… a lesser extent (around -0.5%) vs other anti-hyperglycaemic drugs and primarily act on post-…
inhibitors is modest compared to other anti-hyperglycaemic therapies and they should not …

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

…, M Angelico, V Ankoma-Sey, Q Anstee, R Anty… - The Lancet, 2019 - thelancet.com
Background Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease
that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown …

Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation

…, H Bzioueche, R Dainese, G Bernard, R Anty… - Gut, 2014 - gut.bmj.com
… Optimisation of anti-inflammatory therapy may be considered in quiescent IBD with IBS-like …
Sections were then incubated with secondary biotinylated anti-mouse rabbit antibodies (…

Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH

S Bekri, P Gual, R Anty, N Luciani, M Dahman… - Gastroenterology, 2006 - Elsevier
… cultured hepatocytes is abolished in the presence of anti-IL-6 antibodies; furthermore, … R)
were expressed relative to levels of RPLP0, (ΔCt = Ct R − Ct RPLP0 ). The relative amount of R

[HTML][HTML] ER stress induces NLRP3 inflammasome activation and hepatocyte death

…, C Rovere, O Le Thuc, MC Saint-Paul, R Anty… - Cell death & …, 2015 - nature.com
… the hepatoprotective and anti-… anti-apoptotic signaling pathways in ob/ob mice. The
expression of ER stress (a and b) and apoptotic proteins, presented as Bcl-2 family pro-apoptotic/anti-…

[HTML][HTML] TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

…, MED Allison, GJ Alexander, AC Piguet, R Anty… - Nature …, 2014 - nature.com
… anthropometrics so that BMI could be calculated, and relevant co-morbidity including the
presence of T2DM (fasting glucose ≥7.1 mmol l −1 (≥128 mg dl −1 ) or treatment with anti-…

Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients

…, C Duffaut, S Bonnafous, C Blin-Wakkach, R Anty… - Diabetes, 2012 - Am Diabetes Assoc
… However, the majority of CD11c + DCs in lean AT were CD103 + , suggesting a role on
the induction of fat Foxp3 + CD4 + Treg cells providing anti-inflammatory signals to block AT …

Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial

…, J Boursier, R Anty, E Diaz, D Thabut, R Moirand… - Jama, 2013 - jamanetwork.com
… In vitro, pentoxifylline and corticosteroids are known to be anti-inflammatory molecules.
On the other hand, in humans, pentoxifylline seems to have a protective effect against the …