To determine the clinical evolution of Lyme arthritis, 55 patients who did not receive antibiotic
therapy for erythema chronicum migrans were followed longitudinally for a mean duration …

The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the gastric mucosa are well
documented. The complex mechanisms of gastric damage, however, are not fully …

Background The risk of acquiring Lyme disease is high in areas in which the disease is
endemic, and the development of a safe and effective vaccine is therefore important. Methods …

… We detected TLR1 mRNA in all 7 low responders by polymerase chain reaction with reverse
transcription (RT-PCR; data not shown). Flow cytometric analysis showed, however, that the …

Chikungunya virus (CHIKV) is a single-stranded RNA virus belonging to the family Togaviridae
and genus Alphavirus that causes an acute febrile illness, chikungunya fever, which is …

Background: Lyme disease has a wide spectrum of clinical manifestations. Diagnosis is
usually based on the clinical and serologic picture rather than on microbiological confirmation. …

In a double-blind placebo-controlled trial carried out from 1980 to 1982, 20 patients with
established Lyme arthritis were assigned treatment with 2.4 million U of intramuscular …

Background: The adverse consequences associated with overdiagnosis and overtreatment
of Lyme disease, although previously recognized, have received inadequate attention. …

… Schoen has received consultant fees, speaking fees, and/or honoraria (less than $10,000
each) from UCB and Abbott and (more than $10,000 each) from Roche, Janssen, and Bristol-…

The natural history of asymptomatic seroconversion to Borrelia burgdorferi has been unclear.
We report here, on the basis of a post hoc assessment, the frequency and outcome of …