Background Although much is known about the natural history of systemic lupus erythematosus
(SLE), the development of SLE autoantibodies before the diagnosis of the disease has …

Western blotting (protein blotting or immunoblotting) is a powerful and important procedure
for the immunodetection of proteins post-electrophoresis, particularly proteins that are of low …

Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …

… We found heterozygosity for 40–60% of these markers in the men identified by microsatellite
marker as having 47,XXY in the present study (Scofield RH, Harley JB: unpublished …

Lipid peroxidation has been implicated in a variety of diseases. 4-Hydroxy-2-nonenal (HNE),
a major oxidation by-product, is cytotoxic, mutagenic, and genotoxic, being involved in …

Systemic lupus erythematosus (SLE or lupus) is a complex disease with a multifactoral etiology,
with genetic, hormonal, and environmental influences. Molecular mimicry as a result of …

Our purpose was to compile information on the haematological manifestations of systemic
lupus erythematosus (SLE), namely leucopenia, lymphopenia, thrombocytopenia, …

Context Many human diseases are the result of autoimmune attack, presumably related to a
loss of tolerance to self. Autoimmune disease can be divided into either organ-specific …

METHODS—Participants were recruited through e-mail announcements to campus employees
and through an article in the local newspaper. Individuals of any age with type 2 diabetes…

Oxidative damage mediated by reactive oxygen species results in the generation of deleterious
by-products. The oxidation process itself and the proteins modified by these molecules …