Bupropion: pharmacology and therapeutic applications

KF Foley, KP DeSanty, RE Kast - Expert review of …, 2006 - Taylor & Francis
… Despite these last two trials, most trials with bupropion have shown it to be moderately
effective as an aid to smoking cessation. Interestingly, a history of depression is not a factor in the …

[HTML][HTML] A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the …

RE Kast, JA Boockvar, A Brüning, F Cappello… - Oncotarget, 2013 - ncbi.nlm.nih.gov
… Sertraline is a 306 Da selective serotonin re-uptake inhibitor (SSRI) in common use over the
last twenty years in the treatment of depressed mood [203]. It is usually well-tolerated and is …

Emerging technology: applications of Raman spectroscopy for prostate cancer

RE Kast, SC Tucker, K Killian, M Trexler… - Cancer and Metastasis …, 2014 - Springer
There is a need in prostate cancer diagnostics and research for a label-free imaging
methodology that is nondestructive, rapid, objective, and uninfluenced by water. Raman …

A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice

D Brustolim, R Ribeiro-dos-Santos, RE Kast… - International …, 2006 - Elsevier
In a wide range of human diseases of inflammatory nature like Crohn's disease, pathology
is mediated in part by pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF) or …

Raman spectroscopy to distinguish grey matter, necrosis, and glioblastoma multiforme in frozen tissue sections

SN Kalkanis, RE Kast, ML Rosenblum… - Journal of neuro …, 2014 - Springer
The need exists for a highly accurate, efficient and inexpensive tool to distinguish normal
brain tissue from glioblastoma multiforme (GBM) and necrosis boundaries rapidly, in real-time, …

[HTML][HTML] Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide

…, K Hu, A Fotovati, R Berns, M Pambid, M Luk, RE Kast… - Oncotarget, 2012 - ncbi.nlm.nih.gov
… Tumor re-growth and relapse is a major problem in treating GBM. A growing body of
genetic analysis of GBM suggests that cell cycle and regulatory factors are key drivers of the …

Cancer chemotherapy and cachexia: Mirtazapine and olanzapine are 5‐HT3 antagonists with good antinausea effects

RE Kast, KF Foley - European journal of cancer care, 2007 - Wiley Online Library
Mirtazapine and olanzapine are easy‐to‐use psychiatric drugs with potent antinausea effects.
Ondansetron and later members of the ’setron class are currently standard treatments for …

[HTML][HTML] CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline …

RE Kast, G Karpel-Massler, ME Halatsch - Oncotarget, 2014 - ncbi.nlm.nih.gov
… To develop CUSP9 we found nine re-positioned (re-purposed), already-marketed drugs
that had evidence supporting their ability to inhibit one or more of the identified glioblastoma …

Raman spectroscopy can differentiate malignant tumors from normal breast tissue and detect early neoplastic changes in a mouse model

RE Kast, GK Serhatkulu, A Cao… - Biopolymers …, 2008 - Wiley Online Library
Raman spectroscopy shows potential in differentiating tumors from normal tissue. We used
Raman spectroscopy with near‐infrared light excitation to study normal breast tissue and …

Lithium and hematology: established and proposed uses

D Focosi, A Azzara, RE Kast, G Carulli… - Journal of Leucocyte …, 2009 - academic.oup.com
Lithium (as lithium carbonate) is an unexpensive drug, widely used in psychiatry for over 50
years in treatment of mood instability (bipolar disorder) and as an adjunct to antidepressants…