BACKGROUND Digestive and liver diseases are a source of significant morbidity, mortality,
and health-care costs for the US population. An annual report of the toll of these diseases …

Pharmacologic treatments for Alzheimer’s disease include the cholinesterase inhibitors
donepezil, galantamine, and rivastigmine. We reviewed their evidence by searching MEDLINE ® …

Background: The comparative effectiveness of rheumatoid arthritis therapies is uncertain.
Purpose: To compare the benefits and harms of disease-modifying antirheumatic drugs (…

Background: Second-generation antidepressants dominate the management of major
depressive disorder (MDD), but evidence on the comparative benefits and harms of these agents …

Oribatid mites (Acari: Oribatidae) are the most diverse arthropod group in forest litter and soil,
and they make significant contributions to decomposition as microbial grazers and …

… Financial disclosure: Dr Hansen has received research support from Novartis and Daiichi
Sankyo and has served as an expert witness for Allergan. Drs Gaynes, Gartlehner, Jonas, …

… Regarding the populations studied, Hansen considered only … On the question of the length
of the studies, Hansen took into … Only 7 of the 50 studies reviewed by Hansen (14%) are fixed-…

… safety of biologic agents for RA. … of RA patients reported a more than 50 times greater risk
of tuberculosis (RR 53.0, 95% CI 34.5–89.0) for RA patients treated with infliximab than for RA …

Background: Medication adherence is suboptimal, and clinicians and researchers struggle
with identifying nonadherent patients. Various measures of medication adherence exist, but …

Objectives To propose and test a simple instrument based on seven criteria of study design
to distinguish effectiveness (pragmatic) from efficacy (explanatory) trials while conducting …