Context Stem cell therapy is rapidly developing and has generated excitement and promise
as well as confusion and at times contradictory results in the lay and scientific literature. …

Hematopoietic stem cells (HSCs) are the earliest cells of the immune system, giving rise to
B and T lymphocytes, monocytes, tissue macrophages, and dendritic cells. In animal models, …

Systemic sclerosis (SSc) is a rare disabling autoimmune disease with a similar mortality to
many cancers. Two randomized controlled trials of autologous hematopoietic stem cell …

ContextType 1 diabetes mellitus (DM) results from a cell-mediated autoimmune attack
against pancreatic beta cells. Previous animal and clinical studies suggest that moderate …

Background Non-randomised studies of haemopoietic stem-cell transplantation (HSCT) in
systemic sclerosis have shown improvements in lung function and skin flexibility but high …

Context In 2007, the effects of the autologous nonmyeloablative hematopoietic stem cell
transplantation (HSCT) in 15 patients with type 1 diabetes mellitus (DM) were reported. Most …

Clinical trials have indicated that autologous hematopoietic stem cell transplantation (HSCT)
can persistently suppress inflammatory disease activity in a subset of patients with severe …

Background Autologous non-myeloablative haemopoietic stem cell transplantation is a method
to deliver intense immune suppression. We evaluated the safety and clinical outcome of …

ContextManifestations of systemic lupus erythematosus (SLE) may in most patients be
ameliorated with medications that suppress the immune system. Nevertheless, there remains a …

Background & Aims: Crohn’s disease (CD) is an immunologically mediated inflammatory
disease of the gastrointestinal tract. Due to a high morbidity and/or an increase in mortality in …