Aim Rejection is one of the major causes of late cardiac allograft failure and at present can
only be diagnosed by invasive endomyocardial biopsies. We sought to determine whether …

Early management of respiratory muscle failure using mechanical ventilation and high-dose
abatacept with CD86 receptor occupancy monitoring combined with ruxolitinib may be …

Monoclonal antibodies directed against the immune checkpoint protein cytotoxic T-lymphocyte
antigen-4 (CTLA-4; CD152) have been investigated in metastatic melanoma and other …

Background: Antibody-mediated rejection (AMR) contributes to heart allograft loss. However,
an important knowledge gap remains in terms of the pathophysiology of AMR and how …

Expanded clinical experience with patients taking antiangiogenic compounds has come with
increasing recognition of the renal adverse effects. Because renal histology is rarely sought …

Objective Atypical manifestations have been described in patients with ANCA-associated
vasculitides (AAV), such as pachymeningitis, orbital mass or chronic periaortitis. Because …

Recent advances in immune checkpoint inhibitor (ICPI) development have led to major
improvements in oncology patient outcomes. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) and …

Background Late antibody-mediated rejection (AMR) after heart transplantation is
suspected to be associated with a poor short-term prognosis. Methods A retrospective single-center …

Noninfectious mixed cryoglobulinemic GN (MCGN) has been poorly investigated. We
analyzed presentation and outcome of 80 patients with biopsy-proven MCGN, which were …

Introduction Histologic subtypes of malignant pleural mesothelioma are a major prognostic
indicator and decision denominator for all therapeutic strategies. In an ambiguous case, a …