Background To test whether deficiency in endothelial nitric oxide synthase (eNOS) affects
atherosclerosis development, we compared lesion formation in apolipoprotein E (apoE)/eNOS-…

Background—Inducible nitric oxide synthase (iNOS) is expressed by leukocytes and smooth
muscle cells in atherosclerotic lesions. To test whether NO produced by iNOS deficiency …

GSH is the major antioxidant and detoxifier of xenobiotics in mammalian cells. A strong decrease
of intracellular GSH has been frequently linked to pathological conditions like ischemia/…

Rationale: Growing evidence indicates that oxidative stress contributes markedly to
endothelial dysfunction. The selenoenzyme glutathione peroxidase 4 (Gpx4) is an intracellular …

Tumor cells generate substantial amounts of reactive oxygen species (ROS), engendering
the need to maintain high levels of antioxidants such as thioredoxin (Trx)- and glutathione (…

Background Apolipoprotein E (apoE)/endothelial nitric oxide synthase (eNOS) double
knockout (DKO) mice demonstrate accelerated atherosclerosis and develop abdominal aortic …

Integrin-linked kinase (ILK) is a phosphoinositide 3-kinase-dependent serine/threonine kinase
that interacts with β integrins. Here we show that endothelial cell (EC)-specific deletion of …

The objective of this study was to determine whether absence of endothelial nitric oxide
synthase (eNOS) affects the expression of cell surface adhesion molecules in endothelial cells. …

To study the role of endothelial nitric oxide synthase (eNOS) in cardiac function, we compared
eNOS expression, contractility, and relaxation in the left ventricles of wild-type and eNOS-…

Background All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic
plaques. NOS enzymes in general catalyse NO production. However, under conditions of …