The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic
disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identify …

We tested the hypothesis that de novo copy number variation (CNV) is associated with autism
spectrum disorders (ASDs). We performed comparative genomic hybridization (CGH) on …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Systemic lupus erythematosus (SLE) is a complex, inflammatory autoimmune disease that
affects multiple organ systems. We used global gene expression profiling of peripheral blood …

Much work investigating the inheritance of RA has focussed on the associations between
HLA class II serological specificities and disease. This has demonstrated association with …

Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting ∼1%
of the adult population worldwide, with an estimated heritability of 60%. To identify genes …

European population genetic substructure was examined in a diverse set of >1,000
individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Background Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic
component. Susceptibility to disease has been linked with a region on chromosome 2q. …

Background Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in
which the risk of disease is influenced by complex genetic and environmental contributions. …