THE IDIOPATHIC hypereosinophilic syndrome (HES) is a leukoproliferative disorder, or more
likely disorders, marked by a sustained overproduction of eosinophils. The distinctiveness …

Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions.
Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to …

Background Eosinophilic granulomatosis with polyangiitis is an eosinophilic vasculitis.
Mepolizumab, an anti–interleukin-5 monoclonal antibody, reduces blood eosinophil counts and …

EOSINOPHILS, like neutrophils and basophils, are a type of granulocyte derived from bone
marrow, distinguished by their morphologic features, constituents, products, and …

Background The hypereosinophilic syndrome is a group of diseases characterized by
persistent blood eosinophilia, defined as more than 1500 cells per microliter with end-organ …

BACKGROUND: Hypereosinophilic syndrome (HES) is a heterogeneous group of rare disorders
defined by persistent blood eosinophilia ≥1.5 × 10 9 /L, absence of a secondary cause, …

5-Lipoxygenase pathway-derived products of arachidonic acid released by human
eosinophils activated in vitro have been measured by using radioimmunoassays specific for …

Eosinophils are a prominent cell type in particular host responses such as the response to
helminth infection and allergic disease. Their effector functions have been attributed to their …

Hypereosinophilic syndromes are a heterogeneous group of uncommon disorders characterized
by the presence of marked peripheral blood eosinophilia, tissue eosinophilia, or both, …

Because eosinophils recruited into the airways in allergic diseases are exposed to inhaled
allergens, we evaluated whether eosinophils within the endobronchial lumen can function in …