NF-κB in defense and disease serine residues. Phosphorylated IκBα is then ubiquitinated,
which targets it for degradation by the 26S proteasome (13), thereby releasing NF-κB dimers …

During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …

The Study Group for Risk Factors for Rheumatoid Arthritis was established by the EULAR
Standing Committee on Investigative Rheumatology to facilitate research into the preclinical …

Objective The 1987 American College of Rheumatology (ACR; formerly, the American
Rheumatism Association) classification criteria for rheumatoid arthritis (RA) have been criticized …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Interleukin-17A (IL-17A) is elaborated by the T helper 17 (T H 17) subset of T H cells and
exhibits potent proinflammatory properties in animal models of autoimmunity, including collagen…

Rheumatoid arthritis (RA) is a heterogeneous, prevalent, chronic autoimmune disease
characterized by painful swollen joints and significant disabilities. Symptomatic relief can be …

Objective. To define variations in the cellular infiltrate and in the expression of monokines in
synovial tissue (ST) from rheumatoid arthritis (RA) patients with different durations of …

To identify rheumatoid arthritis risk loci in European populations, we conducted a meta-analysis
of two published genome-wide association (GWA) studies totaling 3,393 cases and …