Analytical characteristics of high-sensitivity cardiac troponin assays

FS Apple, PO Collinson… - Clinical …, 2012 - academic.oup.com
BACKGROUND Cardiac troponins I (cTnI) and T (cTnT) have received international endorsement
as the standard biomarkers for detection of myocardial injury, for risk stratification in …

[HTML][HTML] High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study

…, A Ferry, AG Stirzaker, A Reid, AJ Gray, PO Collinson… - The Lancet, 2015 - thelancet.com
Background Suspected acute coronary syndrome is the commonest reason for emergency
admission to hospital and is a large burden on health-care resources. Strategies to identify …

High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study

…, M Stoddart, F Strachan, S Walker, PO Collinson… - bmj, 2015 - bmj.com
Objective To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin
I assay and sex specific diagnostic thresholds in men and women with suspected acute …

Cardiac troponins: from myocardial infarction to chronic disease

KC Park, DC Gaze, PO Collinson… - Cardiovascular …, 2017 - academic.oup.com
Elucidation of the physiologically distinct subunits of troponin in 1973 greatly facilitated our
understanding of cardiac contraction. Although troponins are expressed in both skeletal and …

Ischemia modified albumin is a sensitive marker of myocardial ischemia after percutaneous coronary intervention

MK Sinha, DC Gaze, JR Tippins, PO Collinson… - Circulation, 2003 - Am Heart Assoc
Background— Ischemia modified albumin (IMA; Ischemia Technologies, Inc) blood levels
rise in patients who develop ischemia during percutaneous coronary intervention (PCI). It is …

Measurement of cardiac troponins

PO Collinson, FG Boa, DC Gaze - Annals of clinical …, 2001 - journals.sagepub.com
The cardiac troponins form part of the regulatory mechanism for muscle contraction. Specific
cardiac isoforms of cardiac troponin T and cardiac troponin I exist and commercially …

[HTML][HTML] High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial

…, A Cruickshank, A Reid, A Gray, PO Collinson… - The Lancet, 2018 - thelancet.com
Background High-sensitivity cardiac troponin assays permit use of lower thresholds for the
diagnosis of myocardial infarction, but whether this improves clinical outcomes is unknown. …

[HTML][HTML] Exercise-induced cardiac troponin T release: a meta-analysis

…, DC Gaze, PO Collinson - … & Science in …, 2007 - westminsterresearch.westminster.ac …
PURPOSE: Cardiac troponin T (cTnT) is a highly specific marker of myocardial damage and
used clinically in the diagnosis of acute myocardial infarction (AMI). Release of cTnT has …

Influence of population selection on the 99th percentile reference value for cardiac troponin assays

PO Collinson, YM Heung, D Gaze, F Boa… - Clinical …, 2012 - academic.oup.com
OBJECTIVE We sought to determine the effect of patient selection on the 99th reference
percentile of 2 sensitive and 1 high-sensitivity (hs) cardiac troponin assays in a well-defined …

Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department

…, S Anwaruddin, RH Christenson, PO Collinson… - American heart …, 2006 - Elsevier
BACKGROUND: Because of possible adverse outcomes, many of the >6 million annual
emergency department (ED) patients with suspected acute coronary syndromes (ACS) undergo …