Objective To describe the clinical and laboratory features of macrophage activation syndrome
as a complication of juvenile systemic lupus erythematosus (SLE). Methods Cases of …

The objective of this work was to develop and validate a set of clinical criteria for the
classification of patients affected by periodic fevers. Patients with inherited periodic fevers (familial …

Systemic juvenile idiopathic arthritis is a heterogeneous form of arthritis in childhood and
represents 10–20% of all juvenile idiopathic arthritides in the Caucasian populations of …

… 1 , Taunton R Southwood, Prudence Manners, John Baum, David N Glass, Jose
Goldenberg, Xiaohu He, Jose Maldonado-Cocco, Javier Orozco-Alcala, Anne-Marie Prieur …

During active disease, patients with systemic-onset juvenile chronic arthritis (S-JCA) demonstrate
a rise and fall in serum interleukin-6 (IL-6) that parallels the classic quotidian fever. To …

Background: There has been a lack of appropriate classification criteria for vasculitis in
children. Objective: To develop a widely accepted general classification for the vasculitides …

Background Systemic juvenile idiopathic arthritis (JIA) is the most severe subtype of JIA;
treatment options are limited. Interleukin-6 plays a pathogenic role in systemic JIA. Methods We …

Objective To determine the distribution of the interleukin‐10 (IL‐10) 5′ flanking region
haplotypes in children with arthritis and in controls, and to investigate the functional significance …

Objective To investigate the safety and efficacy of a recombinant human anti–interleukin‐6 (anti–IL‐6)
receptor monoclonal antibody (MRA) that indirectly inhibits the effects of IL‐6 in …

Objective Familial cold urticaria (FCU) and Muckle‐Wells syndrome (MWS) are dominantly
inherited autoinflammatory disorders that cause rashes, fever, arthralgia, and in some …