A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Background Various observations have suggested that the course of COVID-19 might be
less favourable in patients with inflammatory rheumatic and musculoskeletal diseases …

Background Given the phenotypic similarities between rheumatoid arthritis (RA)–associated
interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we …

Objective To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying
antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA). …

Objective. To measure the prevalence of different types of pulmonary hypertension (PH) and
to identify patients with systemic sclerosis (SSc) at highest risk in a multicenter European …

Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune
system and connective tissue. SSc stands out as a severely incapacitating and life-…

Objectives To analyze the clinical and immunological characteristics at enrollment in a large
prospective cohort of patients with primary Sjögren's syndrome (pSS) and to investigate the …

Question addressed by the study Methotrexate (MTX) is a key anchor drug for rheumatoid
arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication of …

Objective. There is now growing evidence that connective tissue diseases, including systemic
sclerosis (SSc), share a common genetic background. Microarray studies support a pivotal …

A polymorphism on the MUC5B promoter (rs35705950) has been associated with idiopathic
pulmonary fibrosis (IPF) but not with systemic sclerosis (SSc) with interstitial lung disease (…