A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Objective To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying
antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA). …

Background Given the phenotypic similarities between rheumatoid arthritis (RA)–associated
interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we …

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry
genetic research of RA promises to improve power to detect genetic signals, fine-…

Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune
system and connective tissue. SSc stands out as a severely incapacitating and life-…

Question addressed by the study Methotrexate (MTX) is a key anchor drug for rheumatoid
arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication of …

Despite its high prevalence and mortality, little is known about the pathogenesis of rheumatoid
arthritis-associated interstitial lung disease (RA-ILD). Given that familial pulmonary …

Objective. There is now growing evidence that connective tissue diseases, including systemic
sclerosis (SSc), share a common genetic background. Microarray studies support a pivotal …

Objective Systemic sclerosis (SSc) belongs to the group of connective tissue disorders (CTDs),
among which are several disorders characterized by a type I interferon (IFN) signature. …

Introduction Gout is a common arthritis that occurs particularly in patients who frequently have
associated comorbidities that limit the use of conventional therapies. The main mechanism …