To develop criteria for the classification of fibromyalgia, we studied 558 consecutive patients:
293 patients with fibromyalgia and 265 control patients. Interviews and examinations were …

Non-randomised studies of the effects of interventions are critical to many areas of healthcare
evaluation, but their results may be biased. It is therefore important to understand and …

This book is written by three clinical epidemiologists from McMaster University, Ontario,
Canada. It reflects their desire to apply the principles of population epidemiology to the care of …

… Tugwell …

The number of published systematic reviews of studies of healthcare interventions has
increased rapidly and these are used extensively for clinical and policy decisions. Systematic …

Background Our objective was to develop an instrument to assess the methodological
quality of systematic reviews, building upon previous tools, empirical evidence and expert …

A NEW paradigm for medical practice is emerging. Evidence-based medicine de-emphasizes
intuition, unsystematic clinical experience, and pathophysiologic rationale as sufficient …

Background Few meta-analyses of randomised trials assess the quality of the studies
included. Yet there is increasing evidence that trial quality can affect estimates of intervention …

Objective To update the American College of Rheumatology (ACR) 2000 recommendations
for hip and knee osteoarthritis (OA) and develop new recommendations for hand OA. …

Objective. Trials of rheumatoid arthritis (RA) treatments report the average response in
multiple outcome measures for treated patients. It is more clinically relevant to test whether …