Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

M Ohta, JS Greenberger, P Anklesaria, A Bassols… - Nature, 1987 - nature.com
Type-β transforming growth factors (TGF-βs) are polypeptides that act hormonally to control
proliferation and differentiation of many cell types 1,2 . Two distinct homodimeric TGF-β …

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.

P Anklesaria, J Teixido, M Laiho… - Proceedings of the …, 1990 - National Acad Sciences
The precursor for transforming growth factor alpha, pro-TGF-alpha, is a cell surface glycoprotein
that can establish contact with epidermal growth factor (EGF) receptors on adjacent cells…

Cationic Liposome-Mediated E1A Gene Transfer to Human Breast and Ovarian Cancer Cells and Its Biologic Effects: A Phase I Clinical Trial

…, N Sneige, RL Katz, P Anklesaria… - Journal of Clinical …, 2001 - ascopubs.org
PURPOSE: Preclinical studies have demonstrated that the adenovirus type 5 E1A gene is
associated with antitumor activities by transcriptional repression of HER-2/neu and induction …

Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene …

…, DN Fiske, FX Burch, HM Prupas, P Anklesaria… - The Journal of …, 2010 - jrheum.org
Objective. To assess safety and clinical outcomes in patients with inflammatory arthritis after
intraarticular (IA) injection of rAAV2-TNFR:Fc, a recombinant adeno-associated viral vector …

Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor α antagonist gene in inflammatory arthritis: a phase 1 dose-escalation …

…, E Keystone, DE Furst, P Anklesaria… - Annals of the …, 2009 - ard.bmj.com
Objective: To examine the safety and tolerability of a single intra-articular injection of rAAV2-TNFR:Fc,
an adenoassociated virus serotype 2 vector containing the cDNA for the human …

E1A-mediated Paclitaxel Sensitization in HER-2/neu-overexpressing Ovarian Cancer SKOV3.ip1 through Apoptosis Involving the Caspase-3 Pathway

…, M Andreeff, J Price, RW Paul, P Anklesaria… - Clinical cancer …, 2000 - AACR
HER-2/neu-overexpressing breast cancer cells are more resistant to the chemotherapeutic
agent paclitaxel (Taxol) than low-HER-2/neu-expressing breast cancer cells, and the …

Engraftment of a clonal bone marrow stromal cell line in vivo stimulates hematopoietic recovery from total body irradiation.

P Anklesaria, K Kase, J Glowacki… - Proceedings of the …, 1987 - National Acad Sciences
Whether bone marrow stromal cells of donors contribute physiologically to hematopoietic
stem cell reconstitution after marrow transplantation is unknown. To determine the …

A phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 subtype C adeno-associated virus vaccine

…, E Vets, PR Johnson, P Anklesaria… - AIDS research and …, 2008 - liebertpub.com
A novel prophylactic AIDS vaccine candidate, consisting of single-stranded DNA for HIV-1
subtype C gag, protease, and part of reverse transcriptase genes, enclosed within a …

A multicenter phase II study of tgDCC‐E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma

…, N Futran, MC Hung, P Anklesaria… - Head & Neck …, 2002 - Wiley Online Library
Background The anti‐cancer gene, E1A, can be complexed to a lipid carrier, DC‐Cholesterol:DOPE,
to form tgDCC‐E1A, which can be injected directly into tumors. Methods Twenty‐…

A phase 2 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 vaccine based on adeno-associated virus

…, E Chomba, PR Johnson, P Anklesaria… - AIDS research and …, 2010 - liebertpub.com
The recombinant vaccine, tgAAC09, based on an adeno-associated virus serotype 2 (AAV2)
vector encoding HIV-1 subtype C Gag, protease, and part of reverse transcriptase, induced …