Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells
M Ohta, JS Greenberger, P Anklesaria, A Bassols… - Nature, 1987 - nature.com
Type-β transforming growth factors (TGF-βs) are polypeptides that act hormonally to control
proliferation and differentiation of many cell types 1,2 . Two distinct homodimeric TGF-β …
proliferation and differentiation of many cell types 1,2 . Two distinct homodimeric TGF-β …
Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.
P Anklesaria, J Teixido, M Laiho… - Proceedings of the …, 1990 - National Acad Sciences
The precursor for transforming growth factor alpha, pro-TGF-alpha, is a cell surface glycoprotein
that can establish contact with epidermal growth factor (EGF) receptors on adjacent cells…
that can establish contact with epidermal growth factor (EGF) receptors on adjacent cells…
Cationic Liposome-Mediated E1A Gene Transfer to Human Breast and Ovarian Cancer Cells and Its Biologic Effects: A Phase I Clinical Trial
…, N Sneige, RL Katz, P Anklesaria… - Journal of Clinical …, 2001 - ascopubs.org
PURPOSE: Preclinical studies have demonstrated that the adenovirus type 5 E1A gene is
associated with antitumor activities by transcriptional repression of HER-2/neu and induction …
associated with antitumor activities by transcriptional repression of HER-2/neu and induction …
Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene …
…, DN Fiske, FX Burch, HM Prupas, P Anklesaria… - The Journal of …, 2010 - jrheum.org
Objective. To assess safety and clinical outcomes in patients with inflammatory arthritis after
intraarticular (IA) injection of rAAV2-TNFR:Fc, a recombinant adeno-associated viral vector …
intraarticular (IA) injection of rAAV2-TNFR:Fc, a recombinant adeno-associated viral vector …
Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor α antagonist gene in inflammatory arthritis: a phase 1 dose-escalation …
…, E Keystone, DE Furst, P Anklesaria… - Annals of the …, 2009 - ard.bmj.com
Objective: To examine the safety and tolerability of a single intra-articular injection of rAAV2-TNFR:Fc,
an adenoassociated virus serotype 2 vector containing the cDNA for the human …
an adenoassociated virus serotype 2 vector containing the cDNA for the human …
E1A-mediated Paclitaxel Sensitization in HER-2/neu-overexpressing Ovarian Cancer SKOV3.ip1 through Apoptosis Involving the Caspase-3 Pathway
…, M Andreeff, J Price, RW Paul, P Anklesaria… - Clinical cancer …, 2000 - AACR
HER-2/neu-overexpressing breast cancer cells are more resistant to the chemotherapeutic
agent paclitaxel (Taxol) than low-HER-2/neu-expressing breast cancer cells, and the …
agent paclitaxel (Taxol) than low-HER-2/neu-expressing breast cancer cells, and the …
Engraftment of a clonal bone marrow stromal cell line in vivo stimulates hematopoietic recovery from total body irradiation.
P Anklesaria, K Kase, J Glowacki… - Proceedings of the …, 1987 - National Acad Sciences
Whether bone marrow stromal cells of donors contribute physiologically to hematopoietic
stem cell reconstitution after marrow transplantation is unknown. To determine the …
stem cell reconstitution after marrow transplantation is unknown. To determine the …
A phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 subtype C adeno-associated virus vaccine
…, E Vets, PR Johnson, P Anklesaria… - AIDS research and …, 2008 - liebertpub.com
A novel prophylactic AIDS vaccine candidate, consisting of single-stranded DNA for HIV-1
subtype C gag, protease, and part of reverse transcriptase genes, enclosed within a …
subtype C gag, protease, and part of reverse transcriptase genes, enclosed within a …
A multicenter phase II study of tgDCC‐E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma
…, N Futran, MC Hung, P Anklesaria… - Head & Neck …, 2002 - Wiley Online Library
Background The anti‐cancer gene, E1A, can be complexed to a lipid carrier, DC‐Cholesterol:DOPE,
to form tgDCC‐E1A, which can be injected directly into tumors. Methods Twenty‐…
to form tgDCC‐E1A, which can be injected directly into tumors. Methods Twenty‐…
A phase 2 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 vaccine based on adeno-associated virus
…, E Chomba, PR Johnson, P Anklesaria… - AIDS research and …, 2010 - liebertpub.com
The recombinant vaccine, tgAAC09, based on an adeno-associated virus serotype 2 (AAV2)
vector encoding HIV-1 subtype C Gag, protease, and part of reverse transcriptase, induced …
vector encoding HIV-1 subtype C Gag, protease, and part of reverse transcriptase, induced …