Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients

…, DE Furst, N Tyson, N Collinson, PB Lehane - Annals of the …, 2013 - ard.bmj.com
Patricia B Lehane7 … Patients who remained B cell depleted after this time were followed
until peripheral B cells returned to lower limit of normal or baseline, whichever occurred earlier. …

Longterm safety of rituximab: final report of the rheumatoid arthritis global clinical trial program over 11 years

…, DE Furst, S Lacey, PB Lehane - The Journal of …, 2015 - jrheum.org
Objective. Final evaluation of the longterm safety of rituximab (RTX) in rheumatoid arthritis (RA)
up to 11 years. Methods. Pooled observed case analysis of data from patients with …

[HTML][HTML] Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event

…, V Malik, S Lacey, P Brunetta, PB Lehane - Journal of …, 2018 - Springer
This report assesses the observed risk of PML in patients treated with the anti-CD20
monoclonal antibody rituximab in the regulatory authority-approved autoimmune indications …

Multiple courses of rituximab produce sustained clinical and radiographic efficacy and safety in patients with rheumatoid arthritis and an inadequate response to 1 or …

…, JE Loveless, C Chung, P Wong, PB Lehane… - The Journal of …, 2012 - jrheum.org
Objective. This 5-year observational posthoc analysis of the REFLEX study and its open-label
extension assessed clinical efficacy, radiographic response, and safety of rituximab (RTX) …

[PDF][PDF] Phase IIa global study evaluating rituximab for the treatment of pediatric patients with granulomatosis with polyangiitis or microscopic polyangiitis

…, P Brunetta, JC Cooper, PB Lehane… - Arthritis & …, 2022 - Wiley Online Library
Objective To assess the safety, tolerability, pharmacokinetics, and efficacy of rituximab (RTX)
in pediatric patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis …

[PDF][PDF] Long‐Term Safety of Rituximab in Granulomatosis With Polyangiitis and in Microscopic Polyangiitis

PA Merkel, JL Niles, LE Mertz, PB Lehane… - Arthritis Care & …, 2021 - Wiley Online Library
Objective The present study was undertaken to conduct a phase IV, open‐label, prospective
study to characterize the long‐term safety of rituximab in a 4‐year observational registry of …

[HTML][HTML] Risk of malignancies in patients with rheumatoid arthritis treated with rituximab: analyses of global postmarketing safety data and long-term clinical trial data

…, P Kirchner, S Melega, S Lacey, PB Lehane - Rheumatology and …, 2020 - Springer
Introduction Patients with rheumatoid arthritis (RA) are at an increased risk of developing
malignancies, but it is unclear whether this increased risk is the result of disease pathobiology …

[HTML][HTML] Evaluation of serious infection in pediatric patients with low immunoglobulin levels receiving rituximab for granulomatosis with Polyangiitis or microscopic …

…, J Cooper, P Pordeli, P Kirchner, PB Lehane - Rheumatology and …, 2022 - Springer
Introduction The aim of this work was to assess the impact of prolonged low immunoglobulin
(IgG or IgM) serum concentrations on the potential cumulative serious infection (SI) risk in …

Rituximab pediatric drug development: pharmacokinetic and pharmacodynamic modeling to inform regulatory approval for rituximab treatment in patients with …

…, C Chavanne, M Cheu, PB Lehane… - Clinical and …, 2022 - Wiley Online Library
Anti‐neutrophil cytoplasmic antibody‐associated vasculitides granulomatosis with
polyangiitis (GPA) and microscopic polyangiitis (MPA) are rare, potentially organ‐ and life‐…

Correction to: Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event

…, V Malik, S Lacey, P Brunetta, PB Lehane - Journal of …, 2018 - Springer
… Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane 3 , was
originally published electronically on the publisher’s internet portal (currently SpringerLink). …