Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients
…, DE Furst, N Tyson, N Collinson, PB Lehane - Annals of the …, 2013 - ard.bmj.com
… Patricia B Lehane7 … Patients who remained B cell depleted after this time were followed
until peripheral B cells returned to lower limit of normal or baseline, whichever occurred earlier. …
until peripheral B cells returned to lower limit of normal or baseline, whichever occurred earlier. …
Longterm safety of rituximab: final report of the rheumatoid arthritis global clinical trial program over 11 years
…, DE Furst, S Lacey, PB Lehane - The Journal of …, 2015 - jrheum.org
Objective. Final evaluation of the longterm safety of rituximab (RTX) in rheumatoid arthritis (RA)
up to 11 years. Methods. Pooled observed case analysis of data from patients with …
up to 11 years. Methods. Pooled observed case analysis of data from patients with …
[HTML][HTML] Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event
…, V Malik, S Lacey, P Brunetta, PB Lehane - Journal of …, 2018 - Springer
This report assesses the observed risk of PML in patients treated with the anti-CD20
monoclonal antibody rituximab in the regulatory authority-approved autoimmune indications …
monoclonal antibody rituximab in the regulatory authority-approved autoimmune indications …
Multiple courses of rituximab produce sustained clinical and radiographic efficacy and safety in patients with rheumatoid arthritis and an inadequate response to 1 or …
…, JE Loveless, C Chung, P Wong, PB Lehane… - The Journal of …, 2012 - jrheum.org
Objective. This 5-year observational posthoc analysis of the REFLEX study and its open-label
extension assessed clinical efficacy, radiographic response, and safety of rituximab (RTX) …
extension assessed clinical efficacy, radiographic response, and safety of rituximab (RTX) …
[PDF][PDF] Phase IIa global study evaluating rituximab for the treatment of pediatric patients with granulomatosis with polyangiitis or microscopic polyangiitis
…, P Brunetta, JC Cooper, PB Lehane… - Arthritis & …, 2022 - Wiley Online Library
Objective To assess the safety, tolerability, pharmacokinetics, and efficacy of rituximab (RTX)
in pediatric patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis …
in pediatric patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis …
[PDF][PDF] Long‐Term Safety of Rituximab in Granulomatosis With Polyangiitis and in Microscopic Polyangiitis
PA Merkel, JL Niles, LE Mertz, PB Lehane… - Arthritis Care & …, 2021 - Wiley Online Library
Objective The present study was undertaken to conduct a phase IV, open‐label, prospective
study to characterize the long‐term safety of rituximab in a 4‐year observational registry of …
study to characterize the long‐term safety of rituximab in a 4‐year observational registry of …
[HTML][HTML] Risk of malignancies in patients with rheumatoid arthritis treated with rituximab: analyses of global postmarketing safety data and long-term clinical trial data
…, P Kirchner, S Melega, S Lacey, PB Lehane - Rheumatology and …, 2020 - Springer
Introduction Patients with rheumatoid arthritis (RA) are at an increased risk of developing
malignancies, but it is unclear whether this increased risk is the result of disease pathobiology …
malignancies, but it is unclear whether this increased risk is the result of disease pathobiology …
[HTML][HTML] Evaluation of serious infection in pediatric patients with low immunoglobulin levels receiving rituximab for granulomatosis with Polyangiitis or microscopic …
…, J Cooper, P Pordeli, P Kirchner, PB Lehane - Rheumatology and …, 2022 - Springer
Introduction The aim of this work was to assess the impact of prolonged low immunoglobulin
(IgG or IgM) serum concentrations on the potential cumulative serious infection (SI) risk in …
(IgG or IgM) serum concentrations on the potential cumulative serious infection (SI) risk in …
Rituximab pediatric drug development: pharmacokinetic and pharmacodynamic modeling to inform regulatory approval for rituximab treatment in patients with …
…, C Chavanne, M Cheu, PB Lehane… - Clinical and …, 2022 - Wiley Online Library
Anti‐neutrophil cytoplasmic antibody‐associated vasculitides granulomatosis with
polyangiitis (GPA) and microscopic polyangiitis (MPA) are rare, potentially organ‐ and life‐…
polyangiitis (GPA) and microscopic polyangiitis (MPA) are rare, potentially organ‐ and life‐…
Correction to: Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event
…, V Malik, S Lacey, P Brunetta, PB Lehane - Journal of …, 2018 - Springer
… Berger, Vineeta Malik, Stuart Lacey, Paul Brunetta, and Patricia B. Lehane 3 , was
originally published electronically on the publisher’s internet portal (currently SpringerLink). …
originally published electronically on the publisher’s internet portal (currently SpringerLink). …