A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

… When multiple SNPs in the same region (r 2 >0.5) satisfied the above criteria, we picked up
SNPs showing the best p values or SNPs for which probe and primer design for replication …

Background Given the phenotypic similarities between rheumatoid arthritis (RA)–associated
interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we …

… If the p values are greater than the alpha level of 0.05, then the covariates satisfy the
proportional odds assumption. This assumption states that the estimate between each pair of …

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry
genetic research of RA promises to improve power to detect genetic signals, fine-…

… We included in our model all variables identified with a corrected p value < 0.1 in the single
variable analysis 22 , and calculated odds ratios (OR) and 95% confidence intervals (CI). In …

… chronic hypersensitivity pneumonitis and CT scan available, the MUC5B risk polymorphism
was associated with the presence of traction bronchiectasis, suggestive of probable UIP (p<…

… Outside the MHC region, our GWAS analysis revealed 7 top SNPs (P<10 −5 ) … P<10 −5 were
selected for follow-up analysis. Within each locus we selected the SNPs with the strongest (P…

… was found among the replication samples (I 2 =0%), and no difference was found between
the discovery and replication samples (I 2 =0%, test for between-group differences p=0.73). …

… in vitro [23, 25], we considered p.His412Tyr a low penetrant mutation and included it in our
… Our findings support the theory of TERT p.His412Tyr as a low penetrance mutation, with two …