… Nijmegen, The Netherlands P Barrera RFJMLaan PLCM van Riel P N R Dekhuijen* AM Th
… We are also grateful to P Donnelly and JW M van der Meer for the revision of this manuscript…

BACKGROUND & AIMS: Tremelimumab is a monoclonal antibody that blocks cytotoxic T-lymphocyte-associated
antigen 4 (CTLA-4), an inhibitory co-receptor that interferes with T cell …

Background There is a need for biomarkers that can predict anti-tumour necrosis factor (anti-TNF)
treatment outcome in patients with rheumatoid arthritis (RA). Several studies have …

… < 2.5⋅10 −5 ) and nominal for 19 markers in 14 other regions (P < 0.05). Four of the loci …
significantly (P = 0.002). The analysis of all 261 families provided a linkage evidence of P = …

Background: Antibodies directed to proteins containing the non-standard amino acid citrulline,
are extremely specific for rheumatoid arthritis (RA). Peptidylcitrulline can be generated by …

… Only P values less than 0.05 were considered significant. … In the lining, both TLR-2 (median
[25%, 75%] 3 [2, 4] versus 1 [0, 2]; P = 0.007) and TLR-4 (median 2 [1, 4] versus 0 [0, 0.5]; P = …

… (R = 0.63 and P < 0.0003). Synovial staining of IL-32 also correlated with indices of synovial
inflammation (R = 0.80 and P < 0.0001) as well as synovial presence of TNFα (R = 0.68 and …

Highly pathogenic avian influenza (HPAI) A/H5N1 viruses (lineage 2.3.4.4b) are rapidly
invading the Americas, threatening wildlife, poultry, and potentially evolving into the next global …

The purpose of this study was to develop and test three instruments to measure fatigue in
children with cancer from the perspectives of the child, parents and staff. The study consisted of …

… of macroscopic synovitis (P < 0.0005 and P < 0.005, … P < 0.0005 and P < 0.01, respectively).
Cartilage destruction was correlated only with the expression of CD68 in the sublining (P …