ContextNonsteroidal anti-inflammatory drug (NSAID)–induced gastrointestinal (GI) toxic
effects, such as upper GI tract perforations, symptomatic gastroduodenal ulcers, and upper GI …

OBJECTIVE: The epidemiology of Moyamoya disease in mainland China has not been
documented. Therefore, the present study was designed to examine the epidemiological and …

… Peng L Zhao … Peng L Zhao … SP Curtis, A Melian, PL Zhao, DB Rodgers, CL McCormick, M
Lee, CR Lines, and BJ Gertz are employees of Merck & Co., Inc. and have held Merck stocks or …

1-Acetyl-3,-5-diarylpyrazolines have received considerable interests from the fields of
medicinal and agricultural chemistry due to their broad spectrum of biological activities. To …

Cytochrome bc 1 complex (EC 1.10.2.2, bc 1 ), an essential component of the cellular respiratory
chain and the photosynthetic apparatus in photosynthetic bacteria, has been identified …

… blood pressures decreased slightly from baseline in the placebo and etoricoxib groups,
and increased slightly in the naproxen group (the maximum difference between means at any …

Background Most nonsteroidal anti-inflammatory drugs (NSAIDs) are nonselective
cyclooxygenase (COX-1 and COX-2) inhibitors and are associated with a variety of upper …

… The trial inclusion/exclusion criteria should also remain largely unchanged relative to
those that would be in place in absence of the pandemic, except for the possible exclusion of …

Since the publication of the International Conference on Harmonization E5 guideline, new
drug approvals in Japan based on the bridging strategy have been increasing. To further …

Diacylhydrazine derivatives have been identified as one of the most important insect growth
regulators. A variety of diacylhydrazine derivatives were designed and synthesized in recent …