Study Design. A review of the current literature on the role of matrix metalloproteinases in
intervertebral disc degeneration. Objective. To detail the characteristics of matrix …

Sciatica in patients with disk disease was long ascribed to pressure put on the sciatic nerve
root by a herniated disk. However, a role for chemical factors acting in conjunction with this …

… This application also induced an increase of substance P in spinal root and dorsal root ganglia
(23). … Melrose J, Gosh P, Taylor TK. Neutral proteinases of the intervertebral disc. Biochim …

Points essentiels La douleur chronique inexpliquée peut être une manifestation somatique d'une
souffrance psychique souvent non prise en charge. Le lien entre traumatismes …

… Prof P Goupille took part in the study design and data analysis. J Hoyland co-ordinated
laboratory activity, and helped with the design of experimental methodology. Prof MIV Jayson …

Background Patients who have had inadequate response to tumour necrosis factor inhibitors
have fewer treatment options and are generally more treatment refractory to subsequent …

Objective: To study the value of antibodies to citrullinated proteins/peptides for predicting
joint outcomes in patients with recent onset rheumatoid arthritis (RA). Methods: 191 patients …

… Factors included in the stepwise multivariate model were those associated with the status
(case or control) in univariate analysis with a significance level of P < 0.20. We used the …

… Antiperinuclear antibody positivity was only predictive of radiologic progression (P = 0.03),
but there was a slight association with the total damage score at 3 years (P = 0.07). No …

Actualisation des recommandations de la Société française de rhumatologie pour la prise
en charge en pratique des patients atteints de spondyloarthrite (SpA). La SpA est prise en …