Background Narcolepsy is a chronic sleep disorder with strong genetic predisposition causing
excessive daytime sleepiness and cataplexy. A sudden increase in childhood narcolepsy …

Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity,
which can impact disease susceptibility. To examine the relationship between human gut …

Type 1 diabetes is perceived as a chronic immune-mediated disease with a subclinical
prodromal period characterized by selective loss of insulin-producing β-cells in the pancreatic …

It is often stated that type 1 diabetes results from a complex interplay between varying degrees
of genetic susceptibility and environmental factors. While agreeing with this principal, our …

The role of the intestinal microbiota as a regulator of autoimmune diabetes in animal models
is well-established, but data on human type 1 diabetes are tentative and based on studies …

… Outi Vaarala Outi Vaarala is professor of pediatric immunology at Linköping University,
Linköping, Sweden, and works also at the National Public Health Institute, Helsinki, Finland. Her …

Background The 65-kD isoform of glutamic acid decarboxylase (GAD) is a major
autoantigen in patients with type 1 diabetes mellitus. This trial assessed the ability of alum-formulated …

BACKGROUND: Probiotic bacteria are potentially beneficial to maturation of the infant's immune
system. OBJECTIVE: To examine the role of probiotic bacteria in treatment of cow's milk …

Serum lipoproteins contain phospholipids and modified low-density lipoprotein (LDL) may
thus act as a target for antiphospholipid antibodies. Raised concentrations of IgG antibodies …

Background Data concerning the relation between anti-phospholipid (aPL) antibodies and
myocardial infarction in subjects without evidence of overt autoimmune disease are conflicting…