ATP-binding-cassette transporter 1 (ABC1) has been implicated in processes related to
membrane-lipid turnover. Here, using in vivo loss-of-function and in vitro gain-of-function models…

Mutations in the gene encoding ATP-binding cassette transporter 1 (ABC1) have been reported
in Tangier disease 1, 2, 3 (TD), an autosomal recessive disorder that is characterized by …

The identification of defects in ABCA1 as the molecular basis of Tangier disease has
highlighted its crucial role in the loading with phospholipids and cholesterol of nascent …

Programmed cell death is one of the major devices controlling cellular homeostasis.
However, the generation of cell debris that follows the execution phase of apoptosis has to be …

Aim: To evaluate the persistence and adherence of subcutaneous biologics in patients with
psoriatic arthritis (PsA). Patients & methods: Psoriatic arthritis patients who initiated …

Background Omalizumab shows greater clinical benefit with 300 mg dose than with the 150
mg dose. Objective To determine outcomes postwithdrawal, relapse, and re-treatment in …

The loss of ABCA1 function leads to Tangier dyslipidemia in humans and to a Tangier-like
phenotype in mice, by impairing the transformation of nascent apolipoproteins into mature …

Objective To evaluate secukinumab (SEC) 300 mg and 150 mg vs placebo in a United
States–only population of biologic-naïve patients with psoriatic arthritis (PsA). Methods CHOICE …

Background Psoriatic arthritis (PsA) is a chronic, heterogeneous, immune-mediated disease
manifesting as a spectrum of possible inflammatory signs and symptoms. Clinicians need …

The metagenomic approach has greatly accelerated the discovery of new enzymes by giving
access to the genetic potential of microorganisms from various environments. Function-…