Objective. To assess the effect of B cell depletion therapy on effector CD4+ T cell homeostasis
and its relation to objective measures of disease activity in patients with primary Sjögren …

… into ectopic lymphoid structures with segregated T and B cell areas. In approximately 25%
of … We therefore postulated that the effect of B cell depletion therapy on Th17 cells and IL-17 …

On antigen binding by the B-cell receptor (BCR), B cells up-regulate protein expression of
the key downstream signaling molecule Bruton tyrosine kinase (Btk), but the effects of Btk up-…

Objective To assess the effect of abatacept (CTLA‐4Ig), which limits T cell activation, on
homeostasis of CD4+ T cell subsets and T cell–dependent B cell hyperactivity in patients with …

Since the original identification of Bruton’s tyrosine kinase (BTK) as the gene defective in the
primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on …

Objective Bruton's tyrosine kinase (BTK) transmits crucial survival signals from the B cell
receptor (BCR) in B cells. Pharmacologic BTK inhibition effectively diminishes disease …

… ) patients, who almost completely lack peripheral B cells and serum immunoglobulins. BTK
is crucial for B cell development and various B cell functions, including cytokine and natural …

… increase B cell survival following BCR stimulation, but also renders B cells more sensitive
to TLR stimulation, resulting in increased expression of CD80, and IL-10 in activated B cells. …

… In this review, we evaluate how BCR signaling ensures that autoreactive B cells are removed
or silenced during B cell development. Next, we provide an overview of inadvertent B cell …

… escape of autoreactive B cells from negative checkpoints. Therefore, modulating these B cell
… BTKi offers potential in targeting pathogenic B cells and constraining overt B cell activation. …