The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Here
we showed that TIM-4 is expressed on human and mouse macrophages and dendritic cells…

Objective. Rapidly progressive interstitial lung disease (RP-ILD) is a rare but potentially fatal
complication of JDM. The aim of this study was to establish markers for the prediction and …

<p>Familial cold autoinflammatory syndrome, Muckle-Wells syndrome (MWS), and chronic,
infantile, neurological, cutaneous and articular (CINCA) syndrome are dominantly inherited …

OBJECTIVE: To assess the feasibility of T-cell receptor excision circles (TRECs) quantification
for neonatal mass screening of severe combined immunodeficiency (SCID). STUDY …

Adaptive immunity is characterized by the expansion of an Ag-specific T cell population
following Ag exposure. The precise mechanisms, however, that control the expansion and …

The molecular basis of common variable immunodeficiency (CVID) is unknown. To assess
humoral immunity in CVID, we selected 24 patients with early or late onset of disease. X-…

Objective Although Behçet's disease (BD) is a chronic inflammatory disorder of uncertain
aetiology, the existence of familial BD with autosomal-dominant traits suggests that a …

We compared the efficacy and safety of infliximab with intravenous immunoglobulin (IVIG), a
standard therapy, in a phase 3 trial (NCT01596335) for Japanese patients with Kawasaki …

Background : The involvement of neutrophil‐mediated inflammation may play an important
role in the pathogenesis of acute respitory syncytial virus bronchiolitis. However, no …

Juvenile dermatomyositis is the most common type of juvenile idiopathic inflammatory
myopathy mainly affecting the skin and proximal muscles. We have published the Japanese …