[HTML][HTML] Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy

T Wada, K Furuichi, N Sakai, Y Iwata, K Yoshimoto… - Kidney international, 2000 - Elsevier
… Author links open overlay panel Takashi Wada , Kengo Furuichi , Norihiko Sakai , Yasunori
Iwata , Keiichi Yoshimoto , Miho Shimizu , Shin-Ichi Takeda , Kazuya Takasawa , Mitsuhiro …

[HTML][HTML] Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis

N Sakai, AM Tager - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2013 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive and ultimately fatal
accumulation of fibroblasts and extracellular matrix in the lung that distorts its architecture and …

Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis

N Sakai, T Wada, H Yokoyama… - Proceedings of the …, 2006 - National Acad Sciences
Fibrocytes are a distinct population of bloodborne cells that share markers of leukocytes as
well as mesenchymal cells. We hypothesized that CCR7-positive fibrocytes migrate into the …

Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy

N Sakai, T Wada, K Furuichi, Y Iwata… - American Journal of …, 2005 - Elsevier
Background: The involvement of mitogen-activated protein kinase (MAPK) in human diabetic
nephropathy has not been fully investigated. Methods: The presence of cells positive for the …

Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis

T Wada, K Furuichi, N Sakai, Y Iwata… - Journal of the …, 2004 - journals.lww.com
ABSTRACT. Monocyte chemoattractant protein (MCP)-1, also termed monocyte chemotactic
and activating factor (MCAF)/CCL2, plays an important role in progressive organ fibrosis. It …

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

…, F Liu, CK Probst, RA Rahimi, N Sakai… - Science translational …, 2017 - science.org
Persistent myofibroblast activation distinguishes pathological fibrosis from physiological
wound healing, suggesting that therapies selectively inducing myofibroblast apoptosis could …

[HTML][HTML] LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

N Sakai, J Chun, JS Duffield, T Wada… - The FASEB …, 2013 - ncbi.nlm.nih.gov
There has been much recent interest in lysophosphatidic acid (LPA) signaling through one
of its receptors, LPA 1, in fibrotic diseases, but the mechanisms by which LPA-LPA 1 …

[HTML][HTML] MIP-1α and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis

…, K Furuichi, C Segawa-Takaeda, M Shimizu, N Sakai… - Kidney international, 1999 - Elsevier
… Author links open overlay panel Takashi Wada 1 2 3 4 , Kengo Furuichi 1 2 3 4 , Chikako
Segawa-Takaeda 1 2 3 4 , Miho Shimizu 1 2 3 4 , Norihiko Sakai 1 2 3 4 , Shin-Ichi Takeda 1 2 …

[HTML][HTML] The outcome and a new ISN/RPS 2003 classification of lupus nephritis in Japanese

…, S Kokubo, Y Iwata, K Yoshimoto, K Shimizu, N Sakai… - Kidney international, 2004 - Elsevier
… , Satoshi Kokubo , Yasunori Iwata , Keiichi Yoshimoto , Kazuaki Shimizu , Norihiko Sakai
, Kengo Furuichi , The Kanazawa Study Group For Renal Diseases and Hypertension 1 …

Long-term outcomes of Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy

…, A Hara, K Kitagawa, Y Iwata, N Sakai… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE We evaluated the structural-functional relationships and the prognostic factors
for renal events, cardiovascular events, and all-cause mortality in type 2 diabetic patients with …