A comment on this article appears in" Patient-reported outcome measures in arthroplasty
registries Report of the Patient-Reported Outcome Measures Working Group of the …

Many patients with chronic pain do not obtain adequate relief or experience unacceptable
side effects from existing treatments. Moreover, even when clinical trials report positive …

Objective. To provide recommendations for the core outcome domains that should be considered
by investigators conducting clinical trials of the efficacy and effectiveness of treatments …

Background Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is
associated with significant pain and disability. Objectives To assess the effects of …

Significant progress has been made in outcome measurement procedures for osteoarthritis (OA)
clinical trials, and guidelines have been established by the US Food and Drug …

Background Osteoarthritis (OA) is a common joint disorder. In the knee, injections of
corticosteroids into the joint (intraarticular (IA)) may relieve inflammation, and reduce pain and …

Background: In clinical trials, at the group level, results are usually reported as mean and
standard deviation of the change in score, which is not meaningful for most readers. Objective: …

H.1. SYMPTOM MODIFYING DRUGS: The primary outcome variable is a specific aspect of
joint pain, although a ‘signal’ symptom or some measure of function may also be studied. …

Objective Early diffuse scleroderma (systemic sclerosis; SSc) has no proven treatment. This
study was undertaken to examine the efficacy of methotrexate (MTX) in improving the skin …

Background: The patient acceptable symptom state (PASS) is the value beyond which patients
can consider themselves well. This concept can help in interpreting results of clinical trials…