[HTML][HTML] Helicobacter pylori-Mediated Immunity and Signaling Transduction in Gastric Cancer

…, H Tsujimoto, H Ueno, Q Xie, N Shinomiya - Journal of clinical …, 2020 - mdpi.com
Helicobacter pylori infection is a leading cause of gastric cancer, which is the second-most
common cancer-related death in the world. The chronic inflammatory environment in the …

[HTML][HTML] Decreased extra-renal urate excretion is a common cause of hyperuricemia

…, M Hosoyamada, Y Sakurai, N Shinomiya… - Nature …, 2012 - nature.com
ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which
raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate '…

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population

…, H Suzuki, N Hamajima, N Shinomiya - Science translational …, 2009 - science.org
Gout based on hyperuricemia is a common disease with a genetic predisposition, which
causes acute arthritis. The ABCG2/BCRP gene, located in a gout-susceptibility locus on …

[HTML][HTML] Clinical practice guideline for renal hypouricemia

…, S Yamaguchi, I Hisatome, K Ichida, N Shinomiya - Human Cell, 2019 - Springer
Renal hypouricemia (RHUC) is a disease caused by dysfunction of renal urate reabsorption
transporters; however, diagnostic guidance and guidelines for RHUC have been lacking, …

[PDF][PDF] Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia

…, Y Sakurai, S Nonoyama, Y Kanai, N Shinomiya - The American Journal of …, 2008 - cell.com
Renal hypouricemia is an inherited disorder characterized by impaired renal urate (uric acid)
reabsorption and subsequent low serum urate levels, with severe complications such as …

c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion

K Sawada, AR Radjabi, N Shinomiya, E Kistner… - Cancer research, 2007 - AACR
The hepatocyte growth factor receptor c-Met is a receptor tyrosine kinase that plays an
important role in tumor growth by activating mitogenic signaling pathways. The goal of this study …

L‐type amino acid transporter 1 as a potential molecular target in human astrocytic tumors

H Nawashiro, N Otani, N Shinomiya… - … journal of cancer, 2006 - Wiley Online Library
L‐type amino acid transporter 1 (LAT1) is a Na + ‐independent neutral amino acid transport
agency and essential for the transport of large neutral amino acids. LAT1 has been …

Inhibitory Effects of Ginsenoside Rh2 on Tumor Growth in Nude Mice Bearing Human Ovarian Cancer Cells

…, K Ishii, K Kudoh, I Nagata, N Shinomiya - Japanese Journal of …, 1998 - Wiley Online Library
Ginsenoside Rh 2 (Rh 2 ), isolated from an ethanol extract of the processed root of Panax
ginseng CA Meyer, inhibits the growth of B16 melanoma cells. This study was designed to …

[HTML][HTML] Bacterial translocation in gastrointestinal cancers and cancer treatment

K Kouzu, H Tsujimoto, Y Kishi, H Ueno, N Shinomiya - Biomedicines, 2022 - mdpi.com
In recent years, there has been increasing evidence that gut microbiota is associated with the
onset and exacerbation of various diseases, such as gastrointestinal cancer. For instance, …

Proliferation and invasion: plasticity in tumor cells

…, BS Knudsen, R Hay, N Shinomiya… - Proceedings of the …, 2005 - National Acad Sciences
Invasive and proliferative phenotypes are fundamental components of malignant disease,
yet basic questions persist about whether tumor cells can express both phenotypes …