IL-17 is a newly discovered T cell–derived cytokine whose role in osteoclast development has
not been fully elucidated. Treatment of cocultures of mouse hemopoietic cells and primary …

Background Del22q11.2 syndrome is the most frequent known chromosomal microdeletion
syndrome, with an incidence of 1 in 4000–5000 livebirths. It is characterised by a 3-Mb …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were …

Objective To elucidate the direct role of human T cells in the induction of osteoclastogenesis
in rheumatoid arthritis (RA), by studying human monocytes and the pathogenetic roles of …

We carried out a multistage genome-wide association study of type 2 diabetes mellitus in
Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The …

We conducted a genome-wide association study using 207,097 SNP markers in Japanese
individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium …

Objective To evaluate the proposed relationship between persistent reduction of serum urate
into the subsaturating range and reduction in the frequency of acute gouty attacks. Methods …

Through a large-scale case-control association study using 52,608 haplotype-based single
nucleotide polymorphism (SNP) markers, we identified a susceptible locus for myocardial …

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure
and death 1 . We conducted a genome-wide association study (GWAS) in individuals of …

An anticonvulsant, carbamazepine (CBZ), is known to show incidences of cutaneous adverse
drug reactions (cADRs) including Stevens–Johnson syndrome (SJS), toxic epidermal …