Aberrant wound-healing responses to injury have been implicated in the development of
pulmonary fibrosis, but the mediators directing these pathologic responses have yet to be fully …

Neutrophils are pivotal effector cells of innate immunity. Their recruitment into peripheral
tissues is indispensable for host defense. Given their destructive potential, neutrophil entry into …

A large and diverse array of chemoattractants control leukocyte trafficking, but how these
apparently redundant signals collaborate in vivo is still largely unknown. We previously …

Neutrophil recruitment into tissue plays an important role in host defense and disease
pathogenesis, including the inflammatory arthritides. A multitude of diverse chemoattractants have …

TIA-1 and TIAR are two closely related RNA recognition motif (RRM) proteins which possess
three RRM-type RNA binding domains (RRMs 1, 2, and 3). Although both proteins have …

Neutrophil recruitment into the joint is a hallmark of inflammatory arthritides, including
rheumatoid arthritis (RA). In a mouse model of autoantibody-induced inflammatory arthritis, …

Neutrophils are first responders of the immune system, rapidly migrating into affected tissues
in response to injury or infection. To effectively call in this first line of defense, strategically …

Objectives Randomised-controlled trials have recently proven the efficacy of the interleukin (IL)-6
receptor antagonist tocilizumab (TCZ) in giant cell arteritis (GCA). However, the …

The deposition of immune complexes (ICs) in tissues induces a “type III hypersensitivity”
that results in tissue damage and underlies the pathogenesis of many autoimmune diseases. …

Eicosanoids are potent, bioactive, lipid mediators that regulate important components of the
immune response, including defense against infection, ischemia, and injury, as well as …