[HTML][HTML] Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
G Tardif, D Hum, JP Pelletier, N Duval… - BMC musculoskeletal …, 2009 - Springer
Background MMP-13 and IGFBP-5 are important factors involved in osteoarthritis (OA). We
investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, …
investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, …
Patient satisfaction needs as related to knee stability and objective findings after ACL reconstruction using the LARS artificial ligament
P Lavoie, J Fletcher, N Duval - The knee, 2000 - Elsevier
The purposes of this study are to compare patient satisfaction with the objective measurement
of knee stability and assess early complications following ACL reconstruction using a …
of knee stability and assess early complications following ACL reconstruction using a …
Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis
…, JP Pelletier, C Boileau, D Lajeunesse, N Duval… - …, 2009 - academic.oup.com
Objectives. Earlier studies suggest the involvement of osteoprotegerin (OPG), RANK and
RANK ligand (RANKL) in OA subchondral bone metabolism; however, few studies have looked …
RANK ligand (RANKL) in OA subchondral bone metabolism; however, few studies have looked …
A reproducible method for studying three-dimensional knee kinematics
…, G Parent, M Van de Putte, N St-Onge, N Duval… - Journal of …, 2005 - Elsevier
The methods used in movement analysis often rely on the definition of joint coordinate systems
permitting three-dimensional (3D) kinematics. The first aim of this research project was to …
permitting three-dimensional (3D) kinematics. The first aim of this research project was to …
Contribution of H3K4 methylation by SET‐1A to interleukin‐1–induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis …
…, J Martel‐Pelletier, JP Pelletier, N Duval… - Arthritis & …, 2011 - Wiley Online Library
Objective To investigate the role of histone H3 lysine 4 (H3K4) methylation in interleukin‐1β
(IL‐1β)–induced cyclooxygenase 2 (COX‐2) and inducible nitric oxide synthase (iNOS) …
(IL‐1β)–induced cyclooxygenase 2 (COX‐2) and inducible nitric oxide synthase (iNOS) …
Elevated Dickkopf‐2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts
…, É Abed, A Delalandre, N Duval… - Journal of Bone and …, 2011 - academic.oup.com
The Wnt signaling pathway is crucial for osteogenesis and regulates terminal osteoblast
differentiation. Although osteoarthritic (OA) osteoblasts show an abnormal phenotype and poor …
differentiation. Although osteoarthritic (OA) osteoblasts show an abnormal phenotype and poor …
[HTML][HTML] Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing …
…, N Amiable, J Martel-Pelletier, H Fahmi, N Duval… - Arthritis research & …, 2007 - Springer
Proteinase-activated receptors (PARs) belong to a family of G protein-coupled receptors.
PARs are activated by a serine-dependent cleavage generating a tethered activating ligand. …
PARs are activated by a serine-dependent cleavage generating a tethered activating ligand. …
Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes: relevance of purity and production process
SK Tat, JP Pelletier, F Mineau, N Duval… - The Journal of …, 2010 - jrheum.org
Objective. During osteoarthritis (OA), the altered metabolism of cartilage involves proinflammatory
factors and matrix metalloprotease (MMP) activity. Studies showed that chondroitin …
factors and matrix metalloprotease (MMP) activity. Studies showed that chondroitin …
[HTML][HTML] Ceramic-on-ceramic total hip arthroplasty is superior to metal-on-conventional polyethylene at 20-year follow-up: a randomised clinical trial
Background Metal-on-conventional polyethylene (MoPc) bearing wear-related biological
reactions in total hip arthroplasty (THA) continue to raise concerns among young, active …
reactions in total hip arthroplasty (THA) continue to raise concerns among young, active …
Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors
SK Tat, JP Pelletier, D Lajeunesse, H Fahmi, N Duval… - Bone, 2008 - Elsevier
BACKGROUND: Osteoarthritis (OA) is the most common human joint disease. Recent
studies suggest that an abnormal subchondral bone metabolism is intimately involved in the …
studies suggest that an abnormal subchondral bone metabolism is intimately involved in the …