The “basal ganglia” refers to a group of subcortical nuclei responsible primarily for motor
control, as well as other roles such as motor learning, executive functions and behaviors, and …

Although type 1 cannabinoid receptors (CB 1 Rs) are expressed abundantly throughout the
brain, the presence of type 2 cannabinoid receptors (CB 2 Rs) in neurons is still somewhat …

The molecular basis of priming for l-DOPA-induced dyskinesias in Parkinson's disease (PD),
which depends on the indirect pathway of motor control, is not known. In rodents, the …

Rationale Cardiovascular disease is now recognized as the number one cause of death in
the world, and the size of the population at risk continues to increase rapidly. The …

Background and Aims Baclofen has been shown to reduce alcohol consumption in alcohol‐dependent
individuals, but there is marked heterogeneity in response. An association …

The tegmental pedunculopontine nucleus (PPN) is a basal ganglia-related structure that has
recently gained renewed interest as a potential surgical target for the treatment of several …

All patients with sporadic amyotrophic lateral sclerosis (SALS) have TDP-43 inclusions in
their motor neurons, suggesting this protein plays a major role in the disease. Coding …

Aims Buprenorphine is effective at reducing relapse to opioid misuse, morbidity and mortality
in opioid‐dependent patients. Urine drug screening (UDS) to assess adherence is used …

Introduction: Most analyses of blood DNA in sporadic neuromuscular disorders have been
inconclusive. This may be because some genetic variants occur only in brain tissue. We …

Phenotypic variation in amyotrophic lateral sclerosis (ALS) is common, and one atypical form
is the flail arm variant (FAV). Some classic ALS patients carry TARDBP mutations, and so …