User profiles for N. TOPLEY
Nicholas TopleyCardiff University School of Medicine Verified email at cf.ac.uk Cited by 18937 |
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
…, S Horiuchi, N Topley, N YAMAMOTO… - The FASEB …, 2001 - Wiley Online Library
… Yamamoto, N., Fuller, GM The soluble interleukin 6 receptor: mechanisms of production and
implications in … sd for each population (n 15, n 9, n 10 for each of the respective age groups). …
implications in … sd for each population (n 15, n 9, n 10 for each of the respective age groups). …
Encapsulating peritoneal sclerosis: definition, etiology, diagnosis, and treatment
…, H Kawanishi, S Mujais, N Topley… - Peritoneal Dialysis …, 2000 - journals.sagepub.com
The utilization of the peritoneal cavity for dialysis creates the opportunity for alterations in the
function and structure of the peritoneal membrane. The peritoneal membrane has proven, …
function and structure of the peritoneal membrane. The peritoneal membrane has proven, …
Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells
… Using scopoletin (40 nM) and 1 µM peroxidase we fluorimetrically measured 1.73 ± 0.14
and 1.49 ± 0.19 nmol H 2 O 2 /10 6 HMC/hr induced by IL-1α (25 ng/ml) and TNF-α (20 ng/ml). …
and 1.49 ± 0.19 nmol H 2 O 2 /10 6 HMC/hr induced by IL-1α (25 ng/ml) and TNF-α (20 ng/ml). …
[PDF][PDF] Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
…, N Yamamoto, S Rose-John, GM Fuller, N Topley… - Immunity, 2001 - cell.com
… Effluent was also collected from CAPD patients (n … , and levels of KC and MIP-2 were
quantified using ELISA (n … , and inflammatory parameters were analyzed (n 6 mice/condition; *, p …
quantified using ELISA (n … , and inflammatory parameters were analyzed (n 6 mice/condition; *, p …
Morphologic changes in the peritoneal membrane of patients with renal disease
JD Williams, KJ Craig, N Topley… - Journal of the …, 2002 - journals.lww.com
ABSTRACT. This study examined the morphologic features of the parietal peritoneal
membranes of 130 patients undergoing peritoneal dialysis (PD) and compared them with the …
membranes of 130 patients undergoing peritoneal dialysis (PD) and compared them with the …
[HTML][HTML] The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane
JD Williams, N Topley, KJ Craig, RK Mackenzie… - Kidney international, 2004 - Elsevier
… I, N = 36; group II, N = 35), and following division of the patients into two subgroups: (1) anuric
patients—those who passed ≤200 mL urine per 24 hours (group I, N = 11; group II, N = 8); …
patients—those who passed ≤200 mL urine per 24 hours (group I, N = 11; group II, N = 8); …
IL-6 regulates neutrophil trafficking during acute inflammation via STAT3
… Results are expressed as the mean ± SEM (n = at least 4 mice/time point, except for F/F:St1−…
Results are expressed as the mean ± SEM (n = at least 4 mice/time point, except for F/F:St1 …
Results are expressed as the mean ± SEM (n = at least 4 mice/time point, except for F/F:St1 …
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
Interleukin (IL)-6 signaling through its soluble receptor (IL-6 transsignaling) directs transition
between innate and acquired immune responses by orchestrating the chemokine-directed …
between innate and acquired immune responses by orchestrating the chemokine-directed …
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130
…, N Yamamoto, S Rose-John, N Topley… - The Journal of …, 2003 - journals.aai.org
Studies in IL-6-deficient (IL-6−/−) mice highlight that IL-6 contributes to arthritis progression.
However, the molecular mechanism controlling its activity in vivo remains unclear. Using an …
However, the molecular mechanism controlling its activity in vivo remains unclear. Using an …
[PDF][PDF] Interleukin-6 signaling drives fibrosis in unresolved inflammation
…, VB O'Donnell, PR Taylor, BJ Jenkins, N Topley… - Immunity, 2014 - cell.com
… Values reflect the fold-change in submesothelial zone thickness compared to the WT control
group at day 0 (n R 3–12 per group, unpaired t test *p < 0.05 compared to WT day 0, **p < …
group at day 0 (n R 3–12 per group, unpaired t test *p < 0.05 compared to WT day 0, **p < …