[HTML][HTML] Clinical review: goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups
M Cecconi, C Corredor, N Arulkumaran, G Abuella… - Critical care, 2013 - Springer
Patients with limited cardiac reserve are less likely to survive and develop more complications
following major surgery. By augmenting oxygen delivery index (DO 2 I) with a combination …
following major surgery. By augmenting oxygen delivery index (DO 2 I) with a combination …
A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases
N Arulkumaran, RJ Unwin, FWK Tam - Expert opinion on …, 2011 - Taylor & Francis
… N Arulkumaran declares no conflict of interest. … Barden N, Harvey M, Gagne B, Analysis
of single nucleotide polymorphisms in genes in the chromosome 12q24.31 region points to …
of single nucleotide polymorphisms in genes in the chromosome 12q24.31 region points to …
Severe pre-eclampsia and hypertensive crises
N Arulkumaran, L Lightstone - Best Practice & Research Clinical Obstetrics …, 2013 - Elsevier
Hypertensive disorders of pregnancy are one of the leading causes of peripartum morbidity
and mortality globally. Hypertensive disease in pregnancy is associated with a spectrum of …
and mortality globally. Hypertensive disease in pregnancy is associated with a spectrum of …
[HTML][HTML] Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B. 1.1. 7 lineage in London, UK: a whole-genome sequencing and hospital-based …
…, J Moreno-Cuesta, N Arulkumaran… - The Lancet infectious …, 2021 - thelancet.com
… Ct values, where available, were obtained for each sample from an in-house N-gene real
time RT-PCR and compared by Welch's t test. Comparisons of genomic viral read depth were …
time RT-PCR and compared by Welch's t test. Comparisons of genomic viral read depth were …
[HTML][HTML] Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single …
…, Z Hrušková, L Holm, M Weiner, N Arulkumaran… - Kidney international, 2017 - Elsevier
Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare.
Current studies of such ‘double-positive’ cases report small numbers and variable outcomes. …
Current studies of such ‘double-positive’ cases report small numbers and variable outcomes. …
Cardiac complications associated with goal-directed therapy in high-risk surgical patients: a meta-analysis
N Arulkumaran, C Corredor… - British journal of …, 2014 - academic.oup.com
Patients with limited cardiopulmonary reserve are at risk of mortality and morbidity after
major surgery. Augmentation of oxygen delivery index (DO 2 I) with iv fluids and inotropes (goal-…
major surgery. Augmentation of oxygen delivery index (DO 2 I) with iv fluids and inotropes (goal-…
[HTML][HTML] Videolaryngoscopy versus direct laryngoscopy for emergency orotracheal intubation outside the operating room: a systematic review and meta-analysis
N Arulkumaran, J Lowe, R Ions, M Mendoza… - British journal of …, 2018 - Elsevier
Videolaryngoscopy (VL) may improve the success of orotracheal intubation compared with
direct laryngoscopy (DL). We performed a systematic search of PubMed, Embase, and …
direct laryngoscopy (DL). We performed a systematic search of PubMed, Embase, and …
Mitochondrial function in sepsis
N Arulkumaran, CS Deutschman, MR Pinsky… - Shock, 2016 - journals.lww.com
Mitochondria are an essential part of the cellular infrastructure, being the primary site for
high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in …
high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in …
Interstitial lung disease and ANCA-associated vasculitis: a retrospective observational cohort study
N Arulkumaran, N Periselneris, G Gaskin… - …, 2011 - academic.oup.com
… 2.7% (n = 14) of our patients with ANCA-associated vasculitis (n = 510); all had MPO-ANCA
and a clinical diagnosis of MPA, giving a prevalence of 7.2% in patients with MPA (n = 194). …
and a clinical diagnosis of MPA, giving a prevalence of 7.2% in patients with MPA (n = 194). …
[HTML][HTML] Creating complex protocells and prototissues using simple DNA building blocks
… histogram plots of DNA nanotube and fiber protocells, n = 747 and 189, for NT and F,
respectively. E Circularity dot plot of DNA nanotube and fiber protocells, n = 914, 747, 356, 221 and …
respectively. E Circularity dot plot of DNA nanotube and fiber protocells, n = 914, 747, 356, 221 and …