Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

S Kwan Tat, N Amiable, JP Pelletier, C Boileau… - …, 2009 - academic.oup.com
… In an attempt to discriminate a localization pattern of membranous RANK in the OA cartilage
(n = 3), chondrocytes from the superficial (superficial and upper intermediate layers) and …

[HTML][HTML] The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis

A Dumas, N Amiable, JP de Rivero Vaccari… - PLoS …, 2014 - journals.plos.org
… Finally, to confirm the inducible nature of pyrin at the protein level, we analyzed
peritoneal cell lysates by Western blotting using a polyclonal antibody directed against the N-terminal …

[HTML][HTML] Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing …

…, N Amiable, J Martel-Pelletier, H Fahmi, N Duval… - Arthritis research & …, 2007 - Springer
… The cleavage by serine proteases of the PAR N-terminal domains unmasks a new N-terminal
sequence that acts as a tethered ligand, binding and activating the receptor itself [3, 4]. …

Paget's disease of bone: an osteoimmunological disorder?

MS Numan, N Amiable, JP Brown… - … design, development and …, 2015 - Taylor & Francis
Osteoimmunology represents a large area of research resulting from the cross talk between
bone and immune systems. Many cytokines and signaling cascades are involved in the field …

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts

S Kwan Tat, JP Pelletier, N Amiable… - … : Official Journal of …, 2008 - Wiley Online Library
… (n = 32) undergoing total knee arthroplasty (mean ± SD age 71 ± 9 years) or normal subjects
(n = 3… We found that ephrin B2 (n = 3), PGE 2 (n = 5), and IL-17 (n = 4) all markedly reduced …

[HTML][HTML] Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes

S Kwan Tat, JP Pelletier, N Amiable, C Boileau… - Arthritis research & …, 2009 - Springer
… expression level in human normal (n = 5) and osteoarthritic (OA) (n = 8) chondrocytes, and
(… as described in Materials and Methods in normal (n = 4) and OA (n = 4) cartilage or in the …

[HTML][HTML] Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis

…, A Lachhab, A Kerever, AS Julien, N Amiable… - Scientific Reports, 2021 - nature.com
… healthy donors between cytokine levels and CLEC12A expression (n = 10, data not shown).
… Healthy donors were also recruited (n = 16, mean age of 53 ± 8 years, 69% female) with …

Proteinase-activated receptor-2 gene disruption limits the effect of osteoarthritis on cartilage in mice: a novel target in joint degradation

N Amiable, J Martel-Pelletier, B Lussier, SK Tat… - The Journal of …, 2011 - jrheum.org
… = 20), in WT DMM 8W group (n = 20), in PAR-2 knockout CTL group (nonoperated; n = 22),
in PAR-2 knockout DMM 4W group (n = 13), and in PAR-2 KO DMM 8W group (n = 14). Mice …

COVID-19 Vaccine in Immunosuppressed Adults with Autoimmune rheumatic Diseases (COVIAAD): safety, immunogenicity and antibody persistence at 12 months …

I Colmegna, V Valerio, N Amiable, M Useche… - RMD open, 2023 - rmdopen.bmj.com
… arthritis (RA, n=131) on stable treatment; systemic lupus erythematosus (SLE, n=23) on
mycophenolate mofetil (MMF); other rheumatic diseases on prednisone ≥10 mg/day (n=8) or …

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts

N Amiable, SK Tat, D Lajeunesse, N Duval, JP Pelletier… - Bone, 2009 - Elsevier
… These receptors are activated through the cleavage of their N-terminal domain by serine
proteases, which expose a new N-terminal sequence that acts as a tethered ligand, binding and …