Introduction We analyzed the prevalence of cardiovascular (CV) disease in patients with
rheumatoid arthritis (RA) and its association with traditional CV risk factors, clinical features of …

OBJECTIVE: To determine the bioavailability of higher oral doses of methotrexate (MTX) in
adult patients with rheumatoid arthritis (RA). METHODS: A pharmacokinetic analysis was …

There is strong evidence from clinical trials that a ‘treat to target’ strategy is effective in
reaching remission in rheumatoid arthritis (RA). However, the question is whether these results …

Objective To compare the performance of different definitions of remission in a large
multinational cross‐sectional cohort of patients with rheumatoid arthritis (RA). Methods The …

Objective Clinical remission is the ultimate therapeutic goal in rheumatoid arthritis (RA).
Although clinical trials have proven this to be a realistic goal, the concept of targeting at …

We investigated the structural requirements for the binding of bisphosphonates to bone mineral
and the relation between their affinity for bone and their effects on bone resorption in vitro…

Introduction Clinical trials have demonstrated that treatment-to-target (T2T) is effective in
achieving remission in early rheumatoid arthritis (RA). However, the concept of T2T has not …

OBJECTIVE: To study the bioavailability of a divided higher oral dose of methotrexate (MTX),
in comparison to a single dose, in adult patients with rheumatoid arthritis (RA). METHODS: …

Despite considerable evidence on the efficacy and safety of early aggressive treat-to-target (T2T)
strategies in early rheumatoid arthritis (RA), a proportion of patients still fail to reach …

OBJECTIVE: To study which factors are associated with longterm methotrexate (MTX) use in
rheumatoid arthritis (RA). METHODS: All patients with RA who had started MTX after …