Enhanced local production of osteopontin in rheumatoid joints.

…, T Mima, T Ishii, M Umeshita-Sasai… - The Journal of …, 2002 - jrheum.org
OBJECTIVE: To investigate the involvement of osteopontin (OPN) in the pathogenesis of
rheumatoid arthritis (RA), localization and production of OPN were examined in patients with RA…
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Expression of osteopontin at sites of bone erosion in a murine experimental arthritis model of collagen‐induced arthritis: Possible involvement of osteopontin in bone …

…, K Nishioka, M Umeshita‐Sasai… - … : Official Journal of …, 2002 - Wiley Online Library
Objective To investigate the involvement of osteopontin (OPN) in bone destruction in a murine
experimental arthritis model of collagen‐induced arthritis (CIA). Methods The expression …
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Autoantibodies to cyclic citrullinated peptide 2 (CCP2) are superior to other potential diagnostic biomarkers for predicting rheumatoid arthritis in early undifferentiated …

…, Y Harada, Y Katada, H Ikeue, M Umeshita-Sasai… - Clinical …, 2007 - Springer
We evaluated the diagnostic value of anti-cyclic citrullinated peptide 2 (anti-CCP2) antibodies
and other potential diagnostic biomarkers (IgM rheumatoid factor, anti-agalactosyl IgG …
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Enhanced expression and DNA binding activity of two CCAAT/enhancer‐binding protein isoforms, C/EBPβ and C/EBPδ, in rheumatoid synovium

…, S Ohshima, M Umeshita‐Sasai… - … : Official Journal of …, 2000 - Wiley Online Library
Objective To investigate the activation and expression of CCAAT/enhancer‐binding
proteins (C/EBP), especially C/EBPβ and ‐δ, in rheumatoid synovium, and their pathogenic …
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Synergistic effect on the attenuation of collagen induced arthritis in tumor necrosis factor receptor I (TNFRI) and interleukin 6 double knockout mice.

N Yamaguchi, S Ohshima, M Umeshita-Sasai… - The Journal of …, 2003 - jrheum.org
OBJECTIVE: To evaluate any additive effect on attenuation of collagen induced arthritis (CIA)
in tumor necrosis factor receptor I (TNFRI) and interleukin 6 (IL-6) double knockout (DKO) …
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Antigen induced arthritis (AIA) can be transferred by bone marrow transplantation: evidence that interleukin 6 is essential for induction of AIA.

…, K Nishioka, N Yamaguchi, M Umeshita-Sasai… - The Journal of …, 2002 - jrheum.org
OBJECTIVE: To investigate the role of bone marrow cells (BMC) in the induction of antigen
induced arthritis (AIA), the expression of 3 major proinflammatory cytokines, interleukin 1beta …
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