Background Systemic-onset juvenile idiopathic arthritis does not always respond to available
treatments, including antitumour necrosis factor agents. We investigated the efficacy and …

Objective. To assess the longterm safety and effectiveness of tocilizumab (TCZ) in systemic-onset
juvenile idiopathic arthritis (sJIA). Methods. The longterm extension phase of 2 pivotal …

Objectives: The objective of this study is to develop clinical practice guideline (CPG) for
Sjögren’s syndrome (SS) based on recently available clinical and therapeutic evidences. …

Objectives To characterize the phenotypic presentation at diagnosis of childhood-onset
primary SS. Methods The Big Data Sjögren Project Consortium is an international, multicentre …

Sjögren's syndrome (SS) is thought to be uncommon in children. An epidemiological study
to describe the clinical features distinguishing SS in Japanese children was performed by …

The regulatory IL‐10 and TGF‐β1 cytokine gene polymorphisms have been associated with
allergic diseases in different populations, like Caucasian, Chinese and Indians. We …

Background Although there are many reports on Juvenile Idiopathic arthritis-associated uveitis
(JIA-U) from various countries, especially from Europe and North America, there are few …

Background. The contribution that genetic polymorphisms of Toll-like receptor (TLR) 4 and
of CD14—both of which recognize respiratory syncytial virus (RSV) in the innate immune …

In serum proteomics using mass spectrometry, the number of detectable proteins is reduced
due to high-abundance proteins, such as albumin. However, recently developed data-…

Background Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS is
a serious cause of mortality and disability. Early diagnosis of atherosclerosis, which is the …