Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches

M Needham, FL Mastaglia - The lancet neurology, 2007 - thelancet.com
Inclusion body myositis is the most common acquired muscle disease in older individuals,
and its prevalence varies among countries and ethnic groups. The aetiology and …

Progressive myopathy with up-regulation of MHC-I associated with statin therapy

M Needham, V Fabian, W Knezevic, P Panegyres… - Neuromuscular …, 2007 - Elsevier
Statins can cause a necrotizing myopathy and hyperCKaemia which is reversible on cessation
of the drug. What is less well known is a phenomenon whereby statins may induce a …

Prevalence of sporadic inclusion body myositis and factors contributing to delayed diagnosis

M Needham, A Corbett, T Day, F Christiansen… - Journal of Clinical …, 2008 - Elsevier
The prevalence of sporadic inclusion body myositis (sIBM) is variable in different populations
and ethnic groups. A previous survey in Western Australia in 2000 found a prevalence of …

Evaluation and construction of diagnostic criteria for inclusion body myositis

…, AL Mammen, AA Amato, MD Weiss, M Needham… - Neurology, 2014 - AAN Enterprises
Objective: To use patient data to evaluate and construct diagnostic criteria for inclusion
body myositis (IBM), a progressive disease of skeletal muscle. Methods: The literature was …

Use of whole-exome sequencing for diagnosis of limb-girdle muscular dystrophy: outcomes and lessons learned

…, K Jones, A Corbett, SW Reddel, M Needham… - JAMA …, 2015 - jamanetwork.com
Importance To our knowledge, the efficacy of transferring next-generation sequencing from a
research setting to neuromuscular clinics has never been evaluated. Objective To translate …

Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

…, S Mathers, PA McCombe, M Needham… - Science translational …, 2022 - science.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Necrotizing autoimmune myopathy

C Liang, M Needham - Current opinion in rheumatology, 2011 - journals.lww.com
… Liang, Christina a,b ; Needham, Merrilee a,b … Correspondence to Dr Merrilee Needham,
MBBS, FRACP, PhD, Clinic 4, Royal North Shore Hospital, St Leonards, NSW 2065 …

Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease

…, C Liang, F Edema-Hildebrand, C Riley, M Needham… - Neurology, 2013 - AAN Enterprises
Objective: To prospectively determine the reliability and validity of serum fibroblast growth
factor 21 (FGF-21) as a biomarker for mitochondrial disease in a cross-sectional cohort of …

Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy

R Ghaoui, J Palmio, J Brewer, M Lek, M Needham… - Neurology, 2016 - AAN Enterprises
Objective: To report novel disease and pathology due to HSPB8 mutations in 2 families with
autosomal dominant distal neuromuscular disease showing both myofibrillar and rimmed …

Statin myotoxicity: a review of genetic susceptibility factors

M Needham, FL Mastaglia - Neuromuscular Disorders, 2014 - Elsevier
The 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase inhibitors (statins) are
among the most common medications prescribed worldwide, but their efficacy and toxicity vary …