Soluble HLA‐A,‐B,‐C and ‐G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation

P Contini, M Ghio, A Poggi, G Filaci… - European journal of …, 2003 - Wiley Online Library
There is convincing evidence that soluble HLA‐A,‐B,‐C (sHLA‐A,‐B,‐C) and soluble HLA‐G
(sHLA‐G) antigens can induce apoptosis in CD8 + activated T cells although there is …

Gastroesophageal reflux and pulmonary fibrosis in scleroderma: a study using pH-impedance monitoring

…, F Indiveri, R Tutuian, V Savarino, M Ghio - American journal of …, 2009 - atsjournals.org
Rationale: Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) is associated
with increased morbidity and mortality. Gastroesophageal reflux (GER) is considered a …

CD8+ CD28− T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers

…, M Rizzi, F Ferrera, P Balestra, M Ghio… - The Journal of …, 2007 - journals.aai.org
Tumor growth is allowed by its ability to escape immune system surveillance. An important
role in determining tumor evasion from immune control might be played by tumor-infiltrating …

Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients

…, M Furnari, L Sconfienza, M Ghio… - European …, 2013 - Eur Respiratory Soc
The aim of the study was to characterise gastro-oesophageal reflux (GOR) in idiopathic
pulmonary fibrosis (IPF). 40 consecutive IPF patients underwent pulmonary high-resolution …

Impairment of CD8+ T suppressor cell function in patients with active systemic lupus erythematosus

…, M Fravega, M Monetti, P Contini, M Ghio… - The Journal of …, 2001 - journals.aai.org
Alteration of T cell suppression function has been recognized in patients with systemic lupus
erythematosus (SLE). Recently, CD8+ T suppressor lymphocytes (CD8+ Ts) have been …

Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+ CD28− T cells and inhibit both T-cell proliferation and CTL function

…, M Rizzi, S Brenci, P Contini, D Olive, M Ghio… - Human immunology, 2004 - Elsevier
Nonantigen specific CD8 + suppressor T lymphocytes (CD8 + Ts) inhibit T-cell proliferation
of antigen-specific T lymphocytes. The impossibility to generate in vitro these cells has been …

Small intestinal bacterial overgrowth in patients suffering from scleroderma: clinical effectiveness of its eradication

…, F Indiveri, V Savarino, M Ghio - Official journal of the …, 2008 - journals.lww.com
OBJECTIVES After the skin, the gastrointestinal tract is the second most common target of
systemic sclerosis (SSc). AIM Our aims were to investigate orocecal transit time (OCTT) and …

Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis

…, N Panico, M Rizzi, F Kalli, G Conteduca, M Ghio… - Clinical …, 2011 - Elsevier
Aim of the study has been to understand the relationship between TH17 and Treg cell subsets
in patients affected with systemic sclerosis (SSc). Phenotypes and functions of Th17 and …

Gastrointestinal motility disorder assessment in systemic sclerosis

E Savarino, F Mei, A Parodi, M Ghio, M Furnari… - …, 2013 - academic.oup.com
Objectives. SSc is a clinically heterogeneous and generalized disease, characterized by
thickness of the connective tissue of the skin and internal organs, such as the digestive tract, …

Gastrointestinal involvement in systemic sclerosis

…, N de Bortoli, I Martinucci, G Bodini, M Ghio… - La Presse Médicale, 2014 - Elsevier
Systemic sclerosis is an autoimmune chronic disease characterised by microvascular,
muscular and immunologic abnormalities that lead to progressive and systemic deposition of …