OBJECTIVES: To discuss nonsteroidal anti-inflammatory drugs (NSAIDs), their history,
development, mode of action, toxicities, strategies for the prevention of toxicity, and future …

Objective Although patients with rheumatoid arthritis (RA) experience fatigue, little is known
about its causes and consequences, and a fully developed theoretical model explaining the …

While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs)
can cause serious cardiovascular side effects and complications. This has led to a …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Background The value of intensive combination therapy in early rheumatoid arthritis is
unproven. In a multicentre, double-blind, randomised trial (COBRA), we compared the …

… Mart AFJ van de Laar … Mart AFJ van de Laar … Two independent assessors scored radiographs
in sequence according to the Sharp/van der Heijde method. Outcomes were analyzed by …

Objective To study the effect of folates on discontinuation of methotrexate (MTX) as single‐drug
antirheumatic treatment due to toxicity, to determine which type of adverse events are …

Ever since the rise of online support groups it has been presumed that there is an empowering
effect from patients' participating in these groups, despite a lack of evidence to back up …

Objective. To quantify potential risk factors for septic arthritis, in order to identify a basis for
prevention. Methods. The occurrence of potential risk factors for septic arthritis in patients with …

OBJECTIVE: Although much has been expected of the empowering effect of taking part in
online patient support groups, there is no direct evidence thus far for the effects of participation …