[HTML][HTML] GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation
…, CY Lin, TC Chen, K El Omari, M Antonelou… - Nature …, 2022 - nature.com
Neutrophils play essential anti-microbial and inflammatory roles in host defense, however,
their activities require tight regulation as dysfunction often leads to detrimental inflammatory …
their activities require tight regulation as dysfunction often leads to detrimental inflammatory …
[PDF][PDF] Risk factors for severe outcomes in patients with systemic vasculitis and COVID‐19: a binational, registry‐based cohort study
…, J Scott, M Karabayas, M Antonelou… - Arthritis & …, 2021 - Wiley Online Library
Objective COVID‐19 is a novel infectious disease with a broad spectrum of clinical severity.
Patients with systemic vasculitis have an increased risk of serious infections and may be at …
Patients with systemic vasculitis have an increased risk of serious infections and may be at …
Therapeutic myeloperoxidase inhibition attenuates neutrophil activation, ANCA-mediated endothelial damage, and crescentic GN
M Antonelou, E Michaëlsson, RDR Evans… - Journal of the …, 2020 - journals.lww.com
Background Myeloperoxidase released after neutrophil and monocyte activation can
generate reactive oxygen species, leading to host tissue damage. Extracellular glomerular …
generate reactive oxygen species, leading to host tissue damage. Extracellular glomerular …
[HTML][HTML] Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis
J Fehmi, AJ Davies, M Antonelou, S Keddie… - PloS one, 2023 - journals.plos.org
Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults,
mediated by glomerular antibody deposition to an increasing number of newly recognised …
mediated by glomerular antibody deposition to an increasing number of newly recognised …
[HTML][HTML] Risk of COVID-19 disease, dialysis unit attributes, and infection control strategy among London in-center hemodialysis patients
…, E Asgari, ML Ford, N Cole, M Antonelou… - Clinical Journal of the …, 2021 - journals.lww.com
Background and objectives Patients receiving in-center hemodialysis treatment face unique
challenges during the coronavirus disease 2019 (COVID-19) pandemic, specifically the …
challenges during the coronavirus disease 2019 (COVID-19) pandemic, specifically the …
High incidence of arterial and venous thrombosis in antineutrophil cytoplasmic antibody–associated vasculitis
A Kang, M Antonelou, NL Wong, A Tanna… - The Journal of …, 2019 - jrheum.org
Objective. To determine the incidence of arterial thrombotic events (ATE) and venous
thromboembolism (VTE) in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). …
thromboembolism (VTE) in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). …
[HTML][HTML] Identifying prognostic risk factors for poor outcome following COVID-19 disease among in-centre haemodialysis patients: role of inflammation and frailty
H Hendra, G Vajgel, M Antonelou, A Neradova… - Journal of …, 2021 - Springer
Introduction The pandemic of coronavirus disease (COVID-19) has highly affected patients
with comorbidities and frailty who cannot self-isolate, such as individuals undergoing …
with comorbidities and frailty who cannot self-isolate, such as individuals undergoing …
[HTML][HTML] Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
RDR Evans, M Antonelou… - Nature …, 2020 - nature.com
Increased extracellular sodium activates Th17 cells, which provide protection from bacterial
and fungal infections. Whilst high salt diets have been shown to worsen autoimmune disease…
and fungal infections. Whilst high salt diets have been shown to worsen autoimmune disease…
Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis
…, M Khosravi, T Goble, S Carter, M Antonelou… - Annals of the …, 2023 - ard.bmj.com
Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are
autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target …
autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target …
[HTML][HTML] Binding Truths: Atypical Anti− Glomerular Basement Membrane Disease Mediated by IgA Anti− Glomerular Basement Membrane Antibodies Targeting the α1 …
M Antonelou, SR Henderson, G Bhangal… - Kidney International …, 2019 - Elsevier
Anti− glomerular basement membrane (anti-GBM) disease presents with rapidly progressive
glomerulonephritis, often associated with alveolar hemorrhage and characterized …
glomerulonephritis, often associated with alveolar hemorrhage and characterized …