[HTML][HTML] GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation

…, CY Lin, TC Chen, K El Omari, M Antonelou… - Nature …, 2022 - nature.com
Neutrophils play essential anti-microbial and inflammatory roles in host defense, however,
their activities require tight regulation as dysfunction often leads to detrimental inflammatory …

[PDF][PDF] Risk factors for severe outcomes in patients with systemic vasculitis and COVID‐19: a binational, registry‐based cohort study

…, J Scott, M Karabayas, M Antonelou… - Arthritis & …, 2021 - Wiley Online Library
Objective COVID‐19 is a novel infectious disease with a broad spectrum of clinical severity.
Patients with systemic vasculitis have an increased risk of serious infections and may be at …

Therapeutic myeloperoxidase inhibition attenuates neutrophil activation, ANCA-mediated endothelial damage, and crescentic GN

M Antonelou, E Michaëlsson, RDR Evans… - Journal of the …, 2020 - journals.lww.com
Background Myeloperoxidase released after neutrophil and monocyte activation can
generate reactive oxygen species, leading to host tissue damage. Extracellular glomerular …

[HTML][HTML] Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis

J Fehmi, AJ Davies, M Antonelou, S Keddie… - PloS one, 2023 - journals.plos.org
Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults,
mediated by glomerular antibody deposition to an increasing number of newly recognised …

[HTML][HTML] Risk of COVID-19 disease, dialysis unit attributes, and infection control strategy among London in-center hemodialysis patients

…, E Asgari, ML Ford, N Cole, M Antonelou… - Clinical Journal of the …, 2021 - journals.lww.com
Background and objectives Patients receiving in-center hemodialysis treatment face unique
challenges during the coronavirus disease 2019 (COVID-19) pandemic, specifically the …

High incidence of arterial and venous thrombosis in antineutrophil cytoplasmic antibody–associated vasculitis

A Kang, M Antonelou, NL Wong, A Tanna… - The Journal of …, 2019 - jrheum.org
Objective. To determine the incidence of arterial thrombotic events (ATE) and venous
thromboembolism (VTE) in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). …

[HTML][HTML] Identifying prognostic risk factors for poor outcome following COVID-19 disease among in-centre haemodialysis patients: role of inflammation and frailty

H Hendra, G Vajgel, M Antonelou, A Neradova… - Journal of …, 2021 - Springer
Introduction The pandemic of coronavirus disease (COVID-19) has highly affected patients
with comorbidities and frailty who cannot self-isolate, such as individuals undergoing …

[HTML][HTML] Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses

RDR Evans, M Antonelou… - Nature …, 2020 - nature.com
Increased extracellular sodium activates Th17 cells, which provide protection from bacterial
and fungal infections. Whilst high salt diets have been shown to worsen autoimmune disease…

Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis

…, M Khosravi, T Goble, S Carter, M Antonelou… - Annals of the …, 2023 - ard.bmj.com
Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are
autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target …

[HTML][HTML] Binding Truths: Atypical Anti− Glomerular Basement Membrane Disease Mediated by IgA Anti− Glomerular Basement Membrane Antibodies Targeting the α1 …

M Antonelou, SR Henderson, G Bhangal… - Kidney International …, 2019 - Elsevier
Anti− glomerular basement membrane (anti-GBM) disease presents with rapidly progressive
glomerulonephritis, often associated with alveolar hemorrhage and characterized …