[HTML][HTML] Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome
…, M Kodera, E Muroi, K Fujikawa, M Seishima… - PloS one, 2013 - journals.plos.org
Objective To identify similarities and differences in the clinical features of adult Japanese
patients with individual anti-aminoacyl-tRNA synthetase antibodies (anti-ARS Abs). Methods …
patients with individual anti-aminoacyl-tRNA synthetase antibodies (anti-ARS Abs). Methods …
Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study
…, Y Asano, K Sodemoto, M Seishima… - Archives of …, 2011 - jamanetwork.com
Objective To clarify the association of clinical and prognostic features with dermatomyositis (DM)-specific
autoantibodies (Abs) in adult Japanese patients with DM. Design Retrospective …
autoantibodies (Abs) in adult Japanese patients with DM. Design Retrospective …
Myositis‐specific anti‐155/140 autoantibodies target transcription intermediary factor 1 family proteins
…, A Higashi, A Igarashi, M Seishima… - Arthritis & …, 2012 - Wiley Online Library
Objective To identify the 140‐kd autoantigen recognized by anti‐155/140 autoantibodies that
are associated with adult cancer‐associated dermatomyositis (DM) and juvenile DM and to …
are associated with adult cancer‐associated dermatomyositis (DM) and juvenile DM and to …
A randomized double-blind trial of intravenous immunoglobulin for pemphigus
…, K Tamaki, Z Ikezawa, M Takigawa, M Seishima… - Journal of the American …, 2009 - Elsevier
BACKGROUND: Pemphigus is a rare life-threatening intractable autoimmune blistering
disease caused by IgG autoantibodies to desmogleins. It has been difficult to conduct a double-…
disease caused by IgG autoantibodies to desmogleins. It has been difficult to conduct a double-…
Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular …
…, A Ozawa, K Sayama, M Seishima… - The Journal of …, 2017 - Wiley Online Library
Psoriasis, a chronic, immune‐mediated skin disease characterized by red, scaly plaques,
affects approximately 0.3% of the population in Japan. The aim of this open‐label study was to …
affects approximately 0.3% of the population in Japan. The aim of this open‐label study was to …
[HTML][HTML] Clinical utility of an enzyme-linked immunosorbent assay for detecting anti-melanoma differentiation-associated gene 5 autoantibodies
…, A Kawakami, M Mishima, T Suda, M Seishima… - PLoS …, 2016 - journals.plos.org
Objective Autoantibodies to melanoma differentiation-associated gene 5 (MDA5) are specifically
expressed in patients with dermatomyositis (DM) and are associated with a subset of …
expressed in patients with dermatomyositis (DM) and are associated with a subset of …
[HTML][HTML] Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation
…, ME Erdal, M Paradisi, AS Paller, M Seishima… - Journal of investigative …, 2003 - Elsevier
The autosomal recessive disorder lipoid proteinosis results from mutations in extracellular
matrix protein 1 (ECM1), a glycoprotein expressed in several tissues (including skin) and …
matrix protein 1 (ECM1), a glycoprotein expressed in several tissues (including skin) and …
[HTML][HTML] Interferon-γ decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis
…, Y Mizutani, T Fujisawa, Y Banno, M Seishima - Journal of Investigative …, 2014 - Elsevier
Ceramide (CER) with long-chain fatty acids (FAs) in the human stratum corneum (SC) is
important for the skin barrier functions. Changes in the CER profile have been associated with …
important for the skin barrier functions. Changes in the CER profile have been associated with …
Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis …
…, K Okuma, K Takahashi, T Kanbara, M Seishima… - Journal of the American …, 2013 - Elsevier
BACKGROUND: Generalized pustular psoriasis (GPP) is a chronic autoimmune disease
characterized by fever, erythema, and neutrophilic pustules over large areas of the skin. GPP …
characterized by fever, erythema, and neutrophilic pustules over large areas of the skin. GPP …
Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes
K Osada, M Seishima, Y Kitajima - Journal of investigative dermatology, 1997 - Elsevier
We have demonstrated previously that pemphigus vulgaris (PV)-IgG induces activation of
phospholipase C (PLC), production of inositol 1,4,5-trisphosphate, and a rapid transient …
phospholipase C (PLC), production of inositol 1,4,5-trisphosphate, and a rapid transient …