Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular …

…, Y Fujita, T Hashimoto, M Higashiyama… - The Journal of …, 2017 - Wiley Online Library
Psoriasis, a chronic, immune‐mediated skin disease characterized by red, scaly plaques,
affects approximately 0.3% of the population in Japan. The aim of this open‐label study was to …

Prevalence and clinical characteristics of psoriatic arthritis in Japan

…, CT Ritchlin, A Tanaka, M Higashiyama… - The Journal of …, 2015 - jrheum.org
Objective. To investigate the prevalence of psoriatic arthritis (PsA) in Japanese patients with
psoriasis. Methods. A multicenter, noninterventional, retrospective cross-sectional study was …

[HTML][HTML] Utility of the Dermatology Life Quality Index at initiation or switching of biologics in real-life Japanese patients with plaque psoriasis: results from the …

…, M Honma, Y Tada, T Mabuchi, M Higashiyama… - Journal of …, 2021 - Elsevier
Background Plaque psoriasis significantly affects patients’ health-related quality of life. To
aid treatment decisions, not only objective assessment by physicians but also subjective …

Possible role of coexpression of CD9 with membrane‐anchored heparin‐binding EGF‐like growth factor and amphiregulin in cultured human keratinocyte growth

S Inui, S Higashiyama, K Hashimoto… - Journal of cellular …, 1997 - Wiley Online Library
CD9 is a protein with 4 transmembrane domains, and functions as a cell surface antigen.
We have previously reported that CD9 functions as an up‐regulator of membrane‐anchored …

Long‐term efficacy and safety results from an open‐label phase III study (UNCOVER‐J) in Japanese plaque psoriasis patients: impact of treatment withdrawal and …

…, Y Fujita, T Hashimoto, M Higashiyama… - Journal of the …, 2019 - Wiley Online Library
Background Long‐term management of moderate‐to‐severe psoriasis is usually discussed
in terms of continuous administration; however, there are many situations in clinical practice …

Detection of anti-desmocollins I and II autoantibodies in two cases of Hallopeau type pemphigus vegetans by immunoblot analysis

K Hashimoto, T Hashimoto, M Higashiyama… - Journal of …, 1994 - Elsevier
Pemphigus foliaceus (PF) sera react with a 150 kDa antigen, desmoglein (DG), while pemphigus
vulgaris (PV) sera react with a 130 kDa PV antigen. Recent molecular cloning studies …

Activation of monocytes in vivo causes intracellular accumulation of lipoprotein-derived lipids and marked hypocholesterolemia—a possible pathogenesis of …

…, S Nozaki, T Funahashi, C Matsumoto, M Higashiyama… - Atherosclerosis, 1999 - Elsevier
Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disease with generalized xanthomatosis.
However, most cases with NXG are normolipidemic or hypolipidemic. The mechanism …

A case of giant axonal neuropathy showing focal aggregation and hypophosphorylation of intermediate filaments

I Mohri, M Taniike, H Yoshikawa, M Higashiyama… - Brain and …, 1998 - Elsevier
We report here the clinicopathological features of a typical case of giant axonal neuropathy (GAN).
Scanning electron microscopy of the hair of this case revealed an extraordinarily …

Analysis of antigens recognized by autoantibodies in herpes gestationis. Usefulness of immunoblotting using a fusion protein representing an extracellular domain of …

H Murakami, M Amagai, M Higashiyama… - Journal of …, 1996 - Elsevier
Herpes gestationis (HG) is a rare pregnancy-associated disease. The aim of this study was
to compare various immunohistochemical and immunobiochemical techniques with respect …

Work productivity in real‐life employed patients with plaque psoriasis: Results from the ProLOGUE study

…, H Takahashi, Y Tada, M Higashiyama… - The Journal of …, 2022 - Wiley Online Library
Psoriasis poses a substantial economic burden by reducing the work productivity of affected
patients. We aimed to evaluate the negative impact of plaque psoriasis on work productivity …