Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity
phenotype in many Caucasian populations. This association with the obesity phenotype is …

Expression and immunological significance of IFN-γ, a pivotal cytokine in murine lupus,
have not been clearly demonstrated in human systemic lupus erythematosus (SLE). In the …

This study demonstrates that IL-23 stimulates the differentiation of human osteoclasts from
peripheral blood mononuclear cells (PBMC). Furthermore, in vivo blockade of endogenous IL-…

The current study explored our hypothesis that IFN‐γ‐producing human T cells inhibit human
osteoclast formation. Activated T cells derived from human PBMC were divided into IFN‐γ‐…

There is evidence that the obesity phenotype in the Caucasian populations is associated
with variations in several genes, including neuronal growth regulator 1 (NEGR1), SEC16 …

Objective. Interferon regulatory factor 5, an es-tablished susceptibility factor for systemic
lupus erythematosus (SLE), plays a role in type I interferon and proinflammatory cytokine …

Objective Several studies have shown that anti‐C1q antibodies correlate with the occurrence
and activity of nephritis in systemic lupus erythematosus (SLE). However, the significance …

The aberrant production of precursor IL-1α (pre-IL-1α) in skin fibroblasts that are derived
from systemic sclerosis (SSc) is associated with the induction of IL-6 and procollagen, which …

Many papers have reported that osteoclasts play an important role in the pathogenesis of
rheumatoid arthritis (RA); however, when we started to investigate the pathogenesis of RA, the …

IL-23, which is composed of p19 and p40 subunits, is a proinflammatory cytokine that contributes
to the formation and maintenance of Th17 cells in inflammatory autoimmune diseases. …