Levels of inflammatory mediators in circulation are known to increase with age, but the
underlying cause of this age-associated inflammation is debated. We find that, when maintained …

Monocyte phenotype and output changes with age, but why this occurs and how it impacts
anti-bacterial immunity are not clear. We found that, in both humans and mice, circulating …

Before widespread vaccination programmes, potential side-effects and flares after COVID-19
vaccination were frequent reasons for vaccine hesitancy among people with rheumatic …

Objective We investigated prolonged COVID-19 symptom duration, defined as lasting 28
days or longer, among people with systemic autoimmune rheumatic diseases (SARDs). …

Background The impact and consequences of the COVID-19 pandemic on people with
rheumatic disease are unclear. We developed the COVID-19 Global Rheumatology Alliance …

Objective To examine the frequency of, and risk factors for, disease flare following COVID-19
vaccination in patients with systemic rheumatic disease (SRD). Methods An international …

Understanding the efficacy of SARS-CoV-2 vaccination in people on immunosuppressive
drugs, including those with rheumatoid arthritis (RA), is critical for their protection. Vaccine …

The objectives of this study were to ( i ) assess sedentary time and prevalence of screen-based
sedentary behaviors of children with a chronic disease and ( ii ) compare sedentary time …

Objective. IL-23 is a pro-inflammatory cytokine proposed to be central to the development of
autoimmune disease. We investigated whether IL-23, together with the downstream …

Objective. To investigate the stability over 2 weeks of ultrasonographic assessments of
synovial thickness and vascularity in all 10 metacarpophalangeal joints of subjects with …